B
Brian J. Anderson
Researcher at University of Auckland
Publications - 160
Citations - 4828
Brian J. Anderson is an academic researcher from University of Auckland. The author has contributed to research in topics: Population & Analgesic. The author has an hindex of 39, co-authored 160 publications receiving 4239 citations. Previous affiliations of Brian J. Anderson include Boston Children's Hospital & Health Science University.
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Journal ArticleDOI
Tips and Traps Analyzing Pediatric PK Data
TL;DR: This review identifies some of the pitfalls of modeling techniques associated with pitfalls and suggests ideas to circumvent or investigate these hazards.
Journal ArticleDOI
I.V. acetaminophen pharmacokinetics in neonates after multiple doses
Greta M Palmer,M. Atkins,Brian J. Anderson,K. R. Smith,T. J. Culnane,C. M. McNally,Elizabeth J. Perkins,George A. Chalkiadis,Rod W. Hunt,Rod W. Hunt +9 more
TL;DR: In this article, a linear disposition model (zero-order input; first-order elimination) was used to describe time-concentration profiles using population modeling (NONMEM).
PAEDIATRICS I.V. acetaminophen pharmacokinetics in neonates after multiple doses
Greta M Palmer,M. Atkins,Brian J. Anderson,K. R. Smith,T. J. Culnane,C. M. McNally,Elizabeth J. Perkins,George A. Chalkiadis,Rod W. Hunt +8 more
TL;DR: A one-compartment linear disposition model (zero-order input; first-order elimination) was used to describe time-concentration profiles using population modelling (NONMEM) and acetaminophen concentrations between 10 and 23 mg litre(-1) at steady state are predicted after 15 mg kg-1 6-hourly for a neonate of PMA 40 weeks.
Journal ArticleDOI
Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates
Karel Allegaert,Brian J. Anderson,Gunnar Naulaers,Jan de Hoon,René Verbesselt,Anne Debeer,Hugo Devlieger,Dick Tibboel +7 more
TL;DR: Lower doses scaled by age-related clearance and centred on a daily dose of 60 mg/kg per day in a child of 6–8 years with a clearance of 0.25 l/h per kg may be more appropriate.
Journal ArticleDOI
Tramadol disposition in the very young: an attempt to assess in vivo cytochrome P-450 2D6 activity.
Karel Allegaert,Karel Allegaert,Brian J. Anderson,René Verbesselt,Anne Debeer,J. de Hoon,Hugo Devlieger,J. N. van den Anker,J. N. van den Anker,J. N. van den Anker,Dick Tibboel +10 more
TL;DR: There was a weak non-linear relationship between PCA and M1 metabolite clearance, and the impact of CYP2D6 polymorphism on the variability in pharmacokinetics, metabolism and pharmacodynamics of tramadol remains to be established.