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Brian J. P. Huntly
Researcher at University of Cambridge
Publications - 168
Citations - 21295
Brian J. P. Huntly is an academic researcher from University of Cambridge. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 54, co-authored 144 publications receiving 19135 citations. Previous affiliations of Brian J. P. Huntly include Cambridge University Hospitals NHS Foundation Trust & Brigham and Women's Hospital.
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Transcriptional variability accelerates pre-leukemia by cell diversification and perturbation of protein synthesis
Shikha Gupta,Oliver M. Dovey,Ana Filipa Domingues,Oliwia W. Cyran,Caitlin M. Cash,George Giotopoulos,Justyna Rak,Jonathan D. Cooper,Jonathan D. Cooper,Malgorzata Gozdecka,Ryan Asby,Noor Al-Jabery,Victor Hernandez-Hernandez,Sudhakaran Prabakaran,Brian J. P. Huntly,George S. Vassiliou,George S. Vassiliou,Cristina Pina +17 more
TL;DR: In this article, a single-cell RNA-sequencing of pre-leukemia with functional analysis of transformation was performed and it was shown that Kat2a loss results in global variegation of cell identity and accumulation of preleukemic cells.
Journal ArticleDOI
Rearrangements Involving 11q23/KMT2A: Mutational Landscape and Prognostic Implications - Results of the Harmony Alliance AML Database
Alberto Hernández Sánchez,Teresa González,Marta Anna Sobas,Eric Sträng,Castellani Gastone,María Abáigar,Peter J. M. Valk,Angela Villaverde Ramiro,Axel Benner,Klaus H. Metzeler,Jesse M. Tettero,Joaquin Martinez-Lopez,Marta Pratcorona,J. Martinez Elicegui,Ken I. Mills,Christian Thiede,Guillermo Sanz,Konstanze Döhner,Michael Heuser,Torsten Haferlach,Amin T. Turki,Dirk Reinhardt,Renate Schulze-Rath,Martje Barbus,Jesús M. Hernández-Rivas,Brian J. P. Huntly,Gert J. Ossenkoppele,Hartmut Döhner,Lars Bullinger +28 more
Journal ArticleDOI
Long-Term Follow-up of AML Patients Treated Intensively before the Era of Targeted Agents. a Big Data Analysis from the Harmony Collaboration
Marta Anna Sobas,Angela Villaverde Ramiro,Alberto Hernández Sánchez,J. Martinez Elicegui,Teresa González,Raúl Azibeiro Melchor,María Abáigar,L. Tur,Daniele Dall'Olio,Eric Sträng,Jesse M. Tettero,Castellani Gastone,Axel Benner,Konstanze Döhner,Christian Thiede,Amin T. Turki,Klaus H. Metzeler,Torsten Haferlach,F. Damm,Rosa Ayala,Joaquin Martinez-Lopez,Ken I. Mills,Jorge Sierra,Sören Lehmann,Matteo G. Della Porta,Jiri Mayer,Dirk Reinhardt,R. Villoria Medina,Renate Schulze-Rath,Martje Barbus,Jesús M. Hernández-Rivas,Brian J. P. Huntly,Gert J. Ossenkoppele,Hartmut Dohner,Lars Bullinger +34 more
TL;DR: In this paper , the authors analyzed changes in outcome of AML patients treated between 1997-2016 prior to the approval of novel drugs, in order to better understand important factors contributing to patient outcome that might also contribute to the efficacy novel treatment approaches.
Journal ArticleDOI
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression
Haiyang Yun,Haiyang Yun,Nisha Narayan,Shabana Vohra,George Giotopoulos,Annalisa Mupo,Pedro Madrigal,Daniel Sasca,Daniel Sasca,David Lara-Astiaso,Sarah J. Horton,Shuchi Agrawal-Singh,Eshwar Meduri,Faisal Basheer,Ludovica Marando,Malgorzata Gozdecka,Malgorzata Gozdecka,Oliver M. Dovey,Oliver M. Dovey,Aracely Castillo-Venzor,Xiaonan Wang,Paolo Gallipoli,Paolo Gallipoli,Carsten Müller-Tidow,Cameron S. Osborne,George S. Vassiliou,George S. Vassiliou,Brian J. P. Huntly +27 more
TL;DR: In this paper, the authors apply an integrated genomic approach to a murine allelic series that models the two most common mutations in acute myeloid leukemia (AML): Flt3-ITD and Npm1c.