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Brian J. P. Huntly
Researcher at University of Cambridge
Publications - 168
Citations - 21295
Brian J. P. Huntly is an academic researcher from University of Cambridge. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 54, co-authored 144 publications receiving 19135 citations. Previous affiliations of Brian J. P. Huntly include Cambridge University Hospitals NHS Foundation Trust & Brigham and Women's Hospital.
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Journal ArticleDOI
BET inhibitor resistance emerges from leukaemia stem cells
Chun Yew Fong,Omer Gilan,Omer Gilan,Enid Y.N. Lam,Alan F. Rubin,Sarah Ftouni,Dean Tyler,Dean Tyler,Kym Stanley,Devbarna Sinha,Paul Yeh,Paul Yeh,Jessica Kate Morison,George Giotopoulos,Dave Lugo,Philip D. Jeffrey,Stanley Chun-Wei Lee,Christopher L. Carpenter,Richard Gregory,Robert G. Ramsay,Robert G. Ramsay,Steven W. Lane,Omar Abdel-Wahab,Tony Kouzarides,Ricky W. Johnstone,Ricky W. Johnstone,Sarah-Jane Dawson,Sarah-Jane Dawson,Brian J. P. Huntly,Rab K. Prinjha,Anthony T. Papenfuss,Mark A. Dawson,Mark A. Dawson +32 more
TL;DR: It is demonstrated that resistance to BET inhibitors, in human and mouse leukaemia cells, is in part a consequence of increased Wnt/β-catenin signalling, and negative regulation of this pathway results in restoration of sensitivity to I-BET in vitro and in vivo.
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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Marco Sciacovelli,Emanuel Gonçalves,Timothy Isaac Johnson,Vincent Zecchini,Ana S. H. Costa,Edoardo Gaude,Alizee Vercauteren Drubbel,Sebastian Julian Theobald,Sandra R Abbo,Maxine Gia Binh Mg Tran,Maxine Gia Binh Mg Tran,Vinothini Rajeeve,Simone Cardaci,Sarah Foster,Haiyang Yun,Pedro R. Cutillas,Anne Y. Warren,Vincent J. Gnanapragasam,Eyal Gottlieb,Kristian Franze,Brian J. P. Huntly,Eamonn R. Maher,Patrick H. Maxwell,Julio Saez-Rodriguez,Julio Saez-Rodriguez,Christian Frezza +25 more
TL;DR: Fumarate inhibits Tet-mediated demethylation of a regulatory region of the antimetastatic miRNA cluster mir-200ba429, leading to the expression of EMT-related transcription factors and enhanced migratory properties and these epigenetic and phenotypic changes are recapitulated by the incubation of fumarate hydratase-proficient cells with cell-permeable fumarine.
Journal ArticleDOI
Population dynamics of normal human blood inferred from somatic mutations.
Henry Lee-Six,Nina F. Øbro,Mairi Shepherd,Sebastian Grossmann,Kevin J. Dawson,Miriam Belmonte,Robert J. Osborne,Brian J. P. Huntly,Inigo Martincorena,Elizabeth Anderson,Laura O’Neill,Michael R. Stratton,Elisa Laurenti,Anthony R. Green,David G. Kent,Peter J. Campbell +15 more
TL;DR: Analysis of blood from a healthy human show that haematopoietic stem cells increase rapidly in numbers through early life, reaching a stable plateau in adulthood, and contribute to myeloid and B lymphocyte populations throughout life.
Journal ArticleDOI
Targeting Epigenetic Readers in Cancer
TL;DR: The mainstay of cancer research is to investigate the role of chromatin in the immune response to drugs and its role in the development of cancerous cells.
Journal ArticleDOI
The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia
Ross L. Levine,Marc M. Loriaux,Brian J. P. Huntly,Mignon L. Loh,M. Beran,Eric P. Stoffregen,Roland Berger,Jennifer J. Clark,Stephanie G. Willis,Kim Nguyen,Nikki J. Flores,Elihu H. Estey,Norbert Gattermann,Scott A. Armstrong,A. Thomas Look,James D. Griffin,Olivier Bernard,Michael Heinrich,D. Gary Gilliland,Brian J. Druker,Michael W. Deininger +20 more
TL;DR: Data indicate that the JAK2V617F allele is present in acute and chronic myeloidmalignancies but not in lymphoid malignancies.