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Brian L. Largent
Researcher at Johns Hopkins University
Publications - 15
Citations - 2466
Brian L. Largent is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Dopamine receptor & Hippocampal formation. The author has an hindex of 14, co-authored 15 publications receiving 2452 citations. Previous affiliations of Brian L. Largent include Johns Hopkins University School of Medicine.
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Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1- propyl)piperidine
TL;DR: There is a notable similarity between the distribution of (+)3H-3-PPP sites and high-affinity binding sites for psychotomimetic opioids, such as the benzomorphan (+)SKF 10,047.
Journal Article
Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.
TL;DR: Pharmacological and autoradiographic analyses reveal that (+)-[3H]SKF 10,047 labels two sites in brain: a high affinity site resembling the sigma receptor and a second site, labeled with lower affinity, similar to the phencyclidine (PCP) receptor.
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Selective labeling of serotonin uptake sites in rat brain by [3H]citalopram contrasted to labeling of multiple sites by [3H]imipramine.
TL;DR: Inhibition of [3H]citalopram binding by both serotonin and imipramine is consistent with a competitive interaction in both equilibrium and kinetic analyses, and the regional distribution of serotonin sensitive and serotonin-insensitive high affinity binding sites closely resembles that of citalopam binding.
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Ontogeny of the serotonergic projection to rat neocortex: transient expression of a dense innervation to primary sensory areas.
Robert J. D'Amato,Mary E. Blue,Brian L. Largent,David A. Lynch,Dawn J. Ledbetter,Mark E. Molliver,Solomon H. Snyder +6 more
TL;DR: The development of serotonergic innervation to rat cerebral cortex was characterized by immunohistochemical localization of serotonin combined with autoradiographic imaging of serotonin-uptake sites and may exert a trophic influence on the development of cortical circuitry and thalamocortical connections.
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Novel antipsychotic drugs share high affinity for σ receptors
TL;DR: Evaluation de la fixation de 7 nouveaux neuroleptiques a 7 sites de liaison de recepteurs biologiques distincts is presented in this article, where the unique trait of each recepteur is evaluated.