Ontogeny of the serotonergic projection to rat neocortex: transient expression of a dense innervation to primary sensory areas.
Robert J. D'Amato,Mary E. Blue,Brian L. Largent,David A. Lynch,Dawn J. Ledbetter,Mark E. Molliver,Solomon H. Snyder +6 more
TLDR
The development of serotonergic innervation to rat cerebral cortex was characterized by immunohistochemical localization of serotonin combined with autoradiographic imaging of serotonin-uptake sites and may exert a trophic influence on the development of cortical circuitry and thalamocortical connections.Abstract:
The development of serotonergic innervation to rat cerebral cortex was characterized by immunohistochemical localization of serotonin combined with autoradiographic imaging of serotonin-uptake sites. In neonatal rat, a transient, dense, serotonergic innervation appears in all primary sensory areas of cortex. In somatosensory cortex, dense patches of serotonergic innervation are aligned with specialized cellular aggregates called barrels. The dense patches are not apparent after 3 weeks of age, and the serotonergic innervation becomes more uniform in adult neocortex. This precocious neonatal serotonergic innervation may play a transient physiologic role in sensory areas of cortex or may exert a trophic influence on the development of cortical circuitry and thalamocortical connections.read more
Citations
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Structure and function of the brain serotonin system.
Journal ArticleDOI
The developmental role of serotonin: news from mouse molecular genetics
TL;DR: New genetic models that target the serotonin system show that transient alterations in serotonin homeostasis cause permanent changes to adult behaviour and modify the fine wiring of brain connections.
Journal ArticleDOI
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TL;DR: Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.
Journal ArticleDOI
Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children.
Diane C. Chugani,Otto Muzik,Michael E. Behen,Robert Rothermel,James Janisse,Jennifer A. Lee,Harry T. Chugani +6 more
TL;DR: The data suggest that humans undergo a period of high brain serotonin synthesis capacity during childhood, and that this developmental process is disrupted in autistic children.
Journal ArticleDOI
Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells
Asif M. Maroof,Sotirios Keros,Jennifer A. Tyson,Shui-Wang Ying,Yosif Ganat,Florian T. Merkle,Becky Liu,Adam L Goulburn,Edouard G. Stanley,Edouard G. Stanley,Andrew G. Elefanty,Andrew G. Elefanty,Hans Ruedi Widmer,Kevin Eggan,Peter A. Goldstein,Stewart A. Anderson,Stewart A. Anderson,Lorenz Studer +17 more
TL;DR: This study defines the signals sufficient for modeling human ventral forebrain development in vitro and lays the foundation for studying cortical interneuron involvement in human disease pathology.
References
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A Dissertation ON
TL;DR: In this article, the authors describe a system for the recognition of predefined situations in buildings, which is based on a hierarchy of symbols, which are also predefined, and use the perceived situations as basis for decision making in the interaction of the whole system with its environment.
Journal ArticleDOI
Evidence that the early postnatal restriction of the cells of origin of the callosal projection is due to the elimination of axonal collaterals rather than to the death of neurons
TL;DR: Using two fluorescent dyes that are retrogradely transported along axons, it is demonstrated that many of the neurons in the parietal region of the rat cerebral cortex that can be labeled from the contralateral hemisphere early in postnatal development, persist well beyond the period when the callosal projection normally becomes restricted.
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