Showing papers in "European Journal of Pharmacology in 1988"

TL;DR: Based on results, medetomidine can be classified as a potent, selective and specific alpha 2-adrenoceptor agonist.

TL;DR: The data indicate that when the DA nerve terminal is exposed to drugs which release newly synthesized DA, DOPAC declines possibly because intraneuronal monoamine oxidase is deprived of its main substrate.

TL;DR: It is concluded that the terminal guanidino nitrogens of L-arginine are the physiological precursors of endothelium-derived NO.

TL;DR: Comparaison de l'sactivite de l'endotheline, de la neurokinine A et du leucotriene D4 sur le muscle lisse tracheal de cobaye.

TL;DR: The results suggest that one of the actions of kynurenate is to antagonise NMDA responses via an action at the strychnine-insensitive glycine receptor.

TL;DR: MDMA exhibited negligible affinities (greater than 500 microM) at opioid (mu, delta and kappa), central-type benzodiazepine, and corticotropin-releasing factor receptors, and at choline uptake sites and calcium channels.

TL;DR: 125I-labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH2(9)]OVT [corrected] was demonstrated to bind selectively to one population of binding sites in rat uterus and ventral hippocampal membrane preparations, allowing important reductions in membrane protein amount, gain in precision of binding analysis as well as considerably lower exposure times for autoradiography.

TL;DR: This study provides the first evidence that MDMA induces dopamine release in vivo and that this effect is region, time- and dose-dependent.

TL;DR: The results suggest that the unsurmountable blockade of NMDA responses by DNQX and CNQX reflects an antagonist effect mediated at the allosterically linked strychnine-insensitive glycine receptor.

TL;DR: Evaluation de la fixation de 7 nouveaux neuroleptiques a 7 sites de liaison de recepteurs biologiques distincts is presented in this article, where the unique trait of each recepteur is evaluated.

TL;DR: Results suggest that, in addition to its central analgesic action, clonidine can induce peripheral antinociception by an alpha 2-adrenoceptor-mediated local release of enkephalin-like substances.

TL;DR: 5-methyl-urapidil is the antagonist which most clearly discriminates between α1-adrenoceptor subtypes and is the frontrunner in the race to find the next generation of drugs to treat Alzheimer's disease.

TL;DR: In this paper, it was suggested that the psychotomimetic effects of some psychostimulants may derive, at least in part, from their interaction with σ receptors.

TL;DR: It is demonstrated that re- gional vasodilator effects are a prominent feature of the haemodynamic response to the i.p. injection of endothelin in the anaesthetized spontaneously hypertensive (SH) rat treated with a ganglion blocking agent.

TL;DR: The data indicate that the enhanced antinociceptive effects of both agonists in inflammation are mediated by a peripheral, opioid receptor-specific mechanism.

TL;DR: In order to determine whether NAN 190 might serve as a 5-HT 1A antagonist, it was evaluated in rats trained to discriminate 8-OH-DPAT HBr from saline in a 2-lever operant procedure.

TL;DR: Results indicated that agonist activity at the 5-HT1B autoreceptor site may decrease 5- HT release, suggesting a presynaptic locus for this receptor in the somatodendritic region.

TL;DR: The potent and selective non-peptide cholecystokinin (CCK) antagonist L-364,718 enhanced the analgesia induced by acute morphine treatment in the rat tail flick test but did not influence the onset of opioid dependence.

TL;DR: The results suggest that activation of the 5-HT1A receptor induces the secretion of ACTH from the rat pituitary gland.

TL;DR: The data support the presence of a presynaptic M1-receptor mediating inhibition and a postsynaptic, cardiac-like M2- receptor responsible for enhancing neurogenic contractions in rabbit vas deferens.

TL;DR: The pharmacological profile of the 5- HT receptor mediating the inhibition of adenylate cyclase in substantia nigra indicates that this receptor probably corresponds to 5-HT1B binding sites.

TL;DR: D-2 antagonists were ineffective in modifying the motivational properties of opioid agonists and naloxone and suggest that the D-1 receptor is critical for the expression of reinforcing and aversive motivational states.

TL;DR: The results suggest that the endogenous formation of nitric oxide is quantitatively sufficient to influence the coronary vascular tone and thus may play a significant role in the regulation of coronary vascular resistance.

TL;DR: The present results indicate that a one-day test can be used to discriminate between saline- and desipramine-treated rats, and that struggling behavior could be a reliable measure of the positive action of antidepressants.