Brian R. Stoll

TL;DR: Evidence that proliferating cancer cells cause intratumour vessels to compress and collapse is provided to reduce this compressive mechanical force and opening vessels, cytotoxic cancer treatments have the potential to increase blood perfusion, thereby improving drug delivery.

TL;DR: The increased pO2 during anti-VEGFR-2 mAb and hormone ablation therapy may explain the observed beneficial effects of combining antiangiogenic or hormone therapies with radiation treatment, and is critical for optimal scheduling of these treatment modalities.

TL;DR: Model simulations of various antiangiogenic strategies show that those therapies that effectively target both endothelial and endothelial progenitor cells, either by restoring the balance between angiogenic stimulators and inhibitors or by targeting both types of cells directly, are most effective at delaying tumor growth.

TL;DR: A mathematical framework that describes production, diffusion, and degradation of factors in tumor and host tissue and their effect on angiogenesis at local and distal sites is presented and suggests generally that diffusible factors produced by tumors can stimulate responses in adjacent host tissue, preparing it for further tumor invasion.

TL;DR: The potential of MPLSM to noninvasively monitor physiology and pathophysiology both at the tissue and cellular level is demonstrated and used for the first time to obtain high-resolution images of deep tissue lymphatic vessels and show an increased accuracy in quantifying lymphatic size.