Ananth Kadambi

TL;DR: It is suggested that eNOS plays a predominant role in VEGF-induced angiogenesis and vascular permeability in vivo, and selective modulation of eN OS activity is a promising strategy for altering angiogenic and vascular porousness in vivo.

TL;DR: Functional lymphatics associated with mouse tumors expressing normal or elevated levels of vascular endothelial growth factor–C (VEGF-C) are examined to suggest that the functional lymphatics in the tumor margin alone are sufficient for lymphatic metastasis and should be targeted therapeutically.

TL;DR: Mechanistic insights into antitumor vascular effects of PDT are provided and novel strategies for tumor treatment with PDT are suggested and suggested.

TL;DR: Model simulations of various antiangiogenic strategies show that those therapies that effectively target both endothelial and endothelial progenitor cells, either by restoring the balance between angiogenic stimulators and inhibitors or by targeting both types of cells directly, are most effective at delaying tumor growth.

TL;DR: In vivo growth and vascular function in tumors derived from two VEGF-C-overexpressing and mock-transfected cell lines are quantified and suggest that VEGFR-2 signaling is critical for tumor angiogenesis and vascular permeability and that V EGFR-3 signaling does not compensate for VEG FR-2 blockade.