B
Brian R. Wamhoff
Researcher at University of Virginia
Publications - 92
Citations - 7306
Brian R. Wamhoff is an academic researcher from University of Virginia. The author has contributed to research in topics: Microbubbles & Myocyte. The author has an hindex of 37, co-authored 89 publications receiving 6669 citations. Previous affiliations of Brian R. Wamhoff include University of Missouri.
Papers
More filters
Journal ArticleDOI
Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease
TL;DR: The focus of this review is to provide an overview of the current state of knowledge of molecular mechanisms/processes that control differentiation of vascular smooth muscle cells (SMC) during normal development and maturation of the vasculature, as well as how these mechanisms/ processeses are altered in vascular injury or disease.
Journal ArticleDOI
Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2
Alexandra Kadl,Akshaya K. Meher,Poonam Sharma,Monica Y. Lee,Amanda C. Doran,Scott R. Johnstone,Michael R. Elliott,Florian Gruber,Jenny Han,Wenshu Chen,Thomas W. Kensler,Kodi S. Ravichandran,Brant E. Isakson,Brian R. Wamhoff,Norbert Leitinger +14 more
TL;DR: The unique biological properties of Mox macrophages suggest this phenotype may play an important role in atherosclerotic lesion development as well as in other settings of chronic inflammation.
Journal ArticleDOI
Myocardin Is a Key Regulator of CArG-Dependent Transcription of Multiple Smooth Muscle Marker Genes
Tadashi Yoshida,Sanjay Sinha,Frédéric Dandré,Brian R. Wamhoff,Mark H. Hoofnagle,Brandon E. Kremer,Da-Zhi Wang,Eric N. Olson,Gary K. Owens +8 more
TL;DR: Results provide compelling evidence that myocardin plays a key role as a transcriptional coactivator of SMC marker genes through CArG-dependent mechanisms.
Journal ArticleDOI
Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo
TL;DR: It is reported that SMC-restricted binding of SRF to murine SMC gene CArG box chromatin is associated with patterns of posttranslational histone modifications within this chromatin that are specific to the SMC lineage in culture and in vivo, including methylation and acetylation to histone H4 residues.
Journal ArticleDOI
Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis.
TL;DR: Current knowledge in vascular smooth muscle cell phenotypic modulation is summarized and some of the key unresolved challenges and questions requiring further study are identified.