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Norbert Leitinger
Researcher at University of Virginia
Publications - 107
Citations - 8675
Norbert Leitinger is an academic researcher from University of Virginia. The author has contributed to research in topics: Inflammation & Receptor. The author has an hindex of 45, co-authored 93 publications receiving 7426 citations. Previous affiliations of Norbert Leitinger include Medical University of Vienna & University of Düsseldorf.
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Journal ArticleDOI
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Michael R. Elliott,Faraaz B. Chekeni,Paul C. Trampont,Eduardo R. Lazarowski,Alexandra Kadl,Scott F. Walk,Daeho Park,Robin I. Woodson,Marina Ostankovich,Poonam Sharma,Jeffrey J. Lysiak,T. Kendall Harden,Norbert Leitinger,Kodi S. Ravichandran,Kodi S. Ravichandran +14 more
TL;DR: Nucleotides are identified as a critical find-me cue released by apoptotic cells to promote P2Y2-dependent recruitment of phagocytes, and provide evidence for a clear relationship between a find- me signal and efficient corpse clearance in vivo.
Journal ArticleDOI
Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins.
Sohvi Hörkkö,David A. Bird,Elizabeth Miller,Hiroyuki Itabe,Norbert Leitinger,Ganesamoorthy Subbanagounder,Judith A. Berliner,Peter A. Friedman,Edward A. Dennis,Linda K. Curtiss,Wulf Palinski,Joseph L. Witztum +11 more
TL;DR: The cloned monoclonal IgM autoantibodies which bind to epitopes of oxidized low-density lipoprotein from apoE-deficient mice suggest that oxidized phospholipid epitopes, present either as lipids or as lipid-protein adducts, represent one class of ligands involved in the recognition of OxLDL by macrophages.
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Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2
Alexandra Kadl,Akshaya K. Meher,Poonam Sharma,Monica Y. Lee,Amanda C. Doran,Scott R. Johnstone,Michael R. Elliott,Florian Gruber,Jenny Han,Wenshu Chen,Thomas W. Kensler,Kodi S. Ravichandran,Brant E. Isakson,Brian R. Wamhoff,Norbert Leitinger +14 more
TL;DR: The unique biological properties of Mox macrophages suggest this phenotype may play an important role in atherosclerotic lesion development as well as in other settings of chronic inflammation.
Journal ArticleDOI
The role of oxidized phospholipids in atherosclerosis
TL;DR: There is increasing evidence that oxidized phospholipids (OxPLs) play an important role in atherosclerosis. as mentioned in this paper showed that OxPL/apolipoprotein B has been shown to be a prognostic indicator and a separate risk factor for coronary events.
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Induction of Heme Oxygenase-1 Inhibits the Monocyte Transmigration Induced by Mildly Oxidized LDL
TL;DR: It is suggested that HO-1 induced by mildly oxidized LDL may protect against the induction of inflammatory responses in artery wall cells through the production of the antioxidants biliverdin and bilirubin.