W
Wenshu Chen
Researcher at University of Virginia
Publications - 3
Citations - 646
Wenshu Chen is an academic researcher from University of Virginia. The author has contributed to research in topics: Inflammation & Macrophage. The author has an hindex of 3, co-authored 3 publications receiving 566 citations.
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Journal ArticleDOI
Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2
Alexandra Kadl,Akshaya K. Meher,Poonam Sharma,Monica Y. Lee,Amanda C. Doran,Scott R. Johnstone,Michael R. Elliott,Florian Gruber,Jenny Han,Wenshu Chen,Thomas W. Kensler,Kodi S. Ravichandran,Brant E. Isakson,Brian R. Wamhoff,Norbert Leitinger +14 more
TL;DR: The unique biological properties of Mox macrophages suggest this phenotype may play an important role in atherosclerotic lesion development as well as in other settings of chronic inflammation.
Journal ArticleDOI
Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2
Alexandra Kadl,Poonam Sharma,Wenshu Chen,Rachana Agrawal,Akshaya K. Meher,Swetha Rudraiah,Nathaniel Grubbs,Rahul Sharma,Norbert Leitinger +8 more
TL;DR: It is demonstrated that Toll-like receptor 2 (TLR2) translates oxidative tissue damage into inflammatory responses by mediating the effects of oxidized phospholipids and provides new insights into how oxidative stress is linked to acute and chronic inflammation.
Journal ArticleDOI
Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation
Samantha E. Adamson,Rachael Griffiths,Radim Moravec,Subramanian Senthivinayagam,Garren Montgomery,Wenshu Chen,Jenny E. Han,Poonam Sharma,Garrett R. Mullins,Stacey A. Gorski,Jonathan A. Cooper,Alexandra Kadl,Kyle B. Enfield,Thomas J. Braciale,Thurl E. Harris,Norbert Leitinger +15 more
TL;DR: Findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages and suggest that manipulation of Dab2 expression and function may hold therapeutic potential for the treatment of acute and chronic inflammatory disorders.