B
Brian Shin
Researcher at University of Illinois at Chicago
Publications - 8
Citations - 1034
Brian Shin is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Transcription factor & Mesenchyme. The author has an hindex of 8, co-authored 8 publications receiving 991 citations.
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Journal ArticleDOI
Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor
Vladimir V. Kalinichenko,Michael L. Major,Xinhe Wang,Vladimir Petrovic,Joseph Kuechle,Helena M. Yoder,Margaret B. Dennewitz,Brian Shin,Abhishek Datta,Pradip Raychaudhuri,Robert H. Costa +10 more
TL;DR: It is demonstrated that conditional overexpression of Foxm1b protein in osteosarcoma U2OS cells greatly enhances anchorage-independent growth of cell colonies on soft agar and suggests that this (D-Arg)(9)-p19(ARF) 26-44 peptide is a potential therapeutic inhibitor of Fox m1b function during cellular transformation.
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Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor.
Vladimir V. Kalinichenko,Lorena Lim,Donna B. Stolz,Brian Shin,Francisco M. Rausa,Jean C. Clark,Jeffrey A. Whitsett,Simon C. Watkins,Robert H. Costa +8 more
TL;DR: Reduction in the level of Foxf1 caused neonatal pulmonary hemorrhage and abnormalities in alveologenesis, implicating this transcription factor in the regulation of mesenchyme-epithelial interaction critical for lung morphogenesis.
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Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury.
Vladimir V. Kalinichenko,Dibyendu Bhattacharyya,Yan Zhou,Galina A. Gusarova,Wooram Kim,Brian Shin,Robert H. Costa +6 more
TL;DR: It is shown that Foxf1 is expressed in hepatic stellate cells in developing and adult liver, suggesting that a subset of stellates cells originates from septum transversum mesenchyme during mouse embryonic development.
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Haploinsufficiency of the Mouse Forkhead Box f1 Gene Causes Defects in Gall Bladder Development
Vladimir V. Kalinichenko,Yan Zhou,Dibyendu Bhattacharyya,Wooram Kim,Brian Shin,Kalyani Bambal,Robert H. Costa +6 more
TL;DR: It is shown that Foxf1 is expressed in embryonic septum transversum and gall bladder mesenchyme and the phenotype correlates with decreased expression of vascular cell adhesion molecule-1 (VCAM-1), α5 integrin, platelet-derived growth factor receptor α (PDGFRα) and hepatocyte growth factor (HGF) genes, all of which are critical for cellAdhesion, migration, and mesenchymal cell differentiation.
Journal ArticleDOI
The forkhead box F1 transcription factor is expressed in brain and head mesenchyme during mouse embryonic development.
TL;DR: Beta-Gal staining was detected in anterior and posterior pituitary gland, astrocytes of the cerebellum and cerebral cortex, lens and retina of the eye, tracheal cartilage, parathyroid, cortical layer of thymus, capsule of the spleen, coronary arteries, and pancreatic blood vessels in adult Foxf1 +/- mice.