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Brooks Zhongzheng Fu
Researcher at California Institute of Technology
Publications - 1
Citations - 484
Brooks Zhongzheng Fu is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Complementarity determining region. The author has an hindex of 1, co-authored 1 publications receiving 431 citations.
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Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization
Florian Klein,Ron Diskin,Ron Diskin,Johannes F. Scheid,Johannes F. Scheid,Christian Gaebler,Christian Gaebler,Hugo Mouquet,Ivelin S. Georgiev,Marie Pancera,Tongqing Zhou,Reha-Baris Incesu,Brooks Zhongzheng Fu,Priyanthi N. P. Gnanapragasam,Thiago Y. Oliveira,Thiago Y. Oliveira,Michael S. Seaman,Peter D. Kwong,Pamela J. Bjorkman,Michel C. Nussenzweig,Michel C. Nussenzweig +20 more
TL;DR: Structural and functional analyses reveal that somatic mutations in FWR residues enhance breadth and potency by providing increased flexibility and/or direct antigen contact in bNAbs, and FWRs play an essential role beyond scaffolding the CDR loops.