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Bruce D. Hammock
Researcher at University of California, Davis
Publications - 1502
Citations - 64405
Bruce D. Hammock is an academic researcher from University of California, Davis. The author has contributed to research in topics: Epoxide hydrolase 2 & Epoxide hydrolase. The author has an hindex of 111, co-authored 1409 publications receiving 57401 citations. Previous affiliations of Bruce D. Hammock include Georgia Regents University & Polytechnic University of Valencia.
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Mass spectrometry-based metabolomics.
TL;DR: This review presents an overview of the dynamically developing field of mass spectrometry-based metabolomics, a technique that analyzes all detectable analytes in a given sample with subsequent classification of samples and identification of differentially expressed metabolites, which define the sample classes.
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Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
John D. Imig,Bruce D. Hammock +1 more
TL;DR: The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation, antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions, and inhibiting this enzyme would be expected to enhance the beneficial cardiovascular properties of EETs.
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Soluble Epoxide Hydrolase Regulates Hydrolysis of Vasoactive Epoxyeicosatrienoic Acids
Zhigang Yu,Fengyun Xu,Linn M. Huse,Christophe Morisseau,Alison J. Draper,John W. Newman,Carol E. Parker,LeRae Graham,Marguerite M. Engler,Bruce D. Hammock,Darryl C. Zeldin,Deanna L. Kroetz +11 more
TL;DR: These studies identify sEH as a novel therapeutic target for control of blood pressure and the identification of a potent and selective inhibitor of EET hydrolysis will be invaluable in separating the vascular effects of the EET and DHET eicosanoids.
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Epoxide hydrolases: Mechanisms, inhibitor designs, and biological roles
TL;DR: A review of the current understanding of the catalytic mechanism of the epoxide hydrolases suggests that the EHs as a family represent novel drug discovery targets for regulation of blood pressure, inflammation, cancer progression, and the onset of several other diseases.
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Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health
TL;DR: How the pharmacological stabilization of EETs and other natural epoxy-fatty acids could lead to possible disease therapies is discussed.