D
Deanna L. Kroetz
Researcher at University of California, San Francisco
Publications - 153
Citations - 10446
Deanna L. Kroetz is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Gene & Epoxide hydrolase 2. The author has an hindex of 48, co-authored 148 publications receiving 9636 citations. Previous affiliations of Deanna L. Kroetz include Vanderbilt University & University of California.
Papers
More filters
Journal ArticleDOI
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
Susanna S.T. Lee,Thierry Pineau,John Drago,Eric J. Lee,Jennie W. Owens,Deanna L. Kroetz,Pedro M. Fernández-Salguero,Heiner Westphal,Frank J. Gonzalez +8 more
TL;DR: It is demonstrated that mPPAR alpha is the major isoform required for mediating the pleiotropic response resulting from the actions of peroxisome proliferators.
Journal ArticleDOI
Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability.
TL;DR: The abundant 3435C>T SNP appears to be a main factor in allelic variation of ABCB1 mRNA expression in the liver, by changing mRNA stability.
Journal ArticleDOI
Soluble Epoxide Hydrolase Regulates Hydrolysis of Vasoactive Epoxyeicosatrienoic Acids
Zhigang Yu,Fengyun Xu,Linn M. Huse,Christophe Morisseau,Alison J. Draper,John W. Newman,Carol E. Parker,LeRae Graham,Marguerite M. Engler,Bruce D. Hammock,Darryl C. Zeldin,Deanna L. Kroetz +11 more
TL;DR: These studies identify sEH as a novel therapeutic target for control of blood pressure and the identification of a potent and selective inhibitor of EET hydrolysis will be invaluable in separating the vascular effects of the EET and DHET eicosanoids.
Journal ArticleDOI
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.
Deanna L. Kroetz,Christiane Pauli-Magnus,Laura M. Hodges,Conrad C. Huang,Michiko Kawamoto,Susan J. Johns,Doug Stryke,Thomas E. Ferrin,Joseph DeYoung,Travis R. Taylor,Elaine J. Carlson,Ira Herskowitz,Kathleen M. Giacomini,Andrew G. Clark +13 more
TL;DR: This study represents a comprehensive analysis of ABCB1 nucleotide diversity and haplotype structure in different populations and illustrates the importance of haplotype considerations in characterizing the functional consequences ofABCB1 polymorphisms.
Journal ArticleDOI
Human liver carbamazepine metabolism. role of cyp3a4 and cyp2c8 in 10, 11-epoxide formation
Bradley M. Kerr,Kenneth E. Thummel,Colleen J. Wurden,Susan M. Klein,Deanna L. Kroetz,Frank J. Gonzalez,RenéH. Levy +6 more
TL;DR: In this article, the role of CYP3A4 in the formation of carbamazepine-10,11-epoxide was investigated in human liver microsomes.