Bruce H. Noden

TL;DR: In addition to the vector-host components of the murine typhus cycle, a second typhuslike rickettsia, R. felis, is uncovered from the blood of a hospitalized febrile patient and from opossums and their fleas.

TL;DR: This quantitative study indicates that the sporogony of cultured P. falciparum in laboratory-infected A. gambiae is an inefficient process and that the ookinete is the key transitional stage affecting the probability of vector infectivity.

TL;DR: The low but highly variable numbers of sporozoites transmitted in vitro by mosquitoes used in malaria vaccine challenge studies appears to be a reasonable simulation of natural sporozoite transmission.

TL;DR: The ookinete is confirmed as the key development stage affecting the probability of vector infectivity, and new insights into the epidemiology of P. falciparum infections are provided.

TL;DR: This approach provides a framework for identifying mechanisms of susceptibility and evaluating Plasmodium sporogonic development in naturally occurring vector species in nature and indicates that gene frequencies determining susceptibility fluctuated with time in all species, except A. freeborni where susceptibility remained homogenous throughout the study.