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Bruce N. Ames
Researcher at Children's Hospital Oakland Research Institute
Publications - 506
Citations - 132778
Bruce N. Ames is an academic researcher from Children's Hospital Oakland Research Institute. The author has contributed to research in topics: DNA damage & Cancer. The author has an hindex of 158, co-authored 506 publications receiving 129010 citations. Previous affiliations of Bruce N. Ames include Boston Children's Hospital & Laboratory of Molecular Biology.
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Journal ArticleDOI
Mutagenesis and carcinogenesis: endogenous and exogenous factors.
TL;DR: In the evolutionary war between plants and animals, animals have developed layers of general defenses, almost all inducible, against a world of natural toxic chemicals, which means the authors are well buffered against toxicity at low doses from both man‐made and natural chemicals.
Journal ArticleDOI
Nature's chemicals and synthetic chemicals: comparative toxicology.
TL;DR: The finding that in high-dose tests, a high proportion of both natural and synthetic chemicals are carcinogens, mutagens, teratogens, and clastogens undermines current regulatory efforts to protect public health from synthetic chemicals based on these tests.
Book ChapterDOI
Measurement of antioxidants in human blood plasma.
TL;DR: The HPLC-EC technique combines selectivity with high sensitivity for measuring both water- and lipid-soluble antioxidants and allows one to measure a panel of antioxidants in a small volume of plasma.
Journal ArticleDOI
An alkyl hydroperoxide reductase induced by oxidative stress in Salmonella typhimurium and Escherichia coli: genetic characterization and cloning of ahp.
Gisela Storz,Fredric S. Jacobson,Louis A. Tartaglia,Robin W. Morgan,L A Silveira,Bruce N. Ames +5 more
TL;DR: Two classes of oxidant-resistant ahp mutants which overexpress the two proteins were isolated and mapped and cloned from Salmonella typhimurium and Escherichia coli complemented the cumene hydroperoxide sensitivity of the ahp deletion strains and restored expression of the F52a and C22 proteins.
Journal ArticleDOI
Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage
TL;DR: The induction of CYP1A1 appears to lead to a leak of oxygen radicals and consequent oxidative DNA damage that could lead to mutation and cancer.