B
Bruce N. Ames
Researcher at Children's Hospital Oakland Research Institute
Publications - 506
Citations - 132778
Bruce N. Ames is an academic researcher from Children's Hospital Oakland Research Institute. The author has contributed to research in topics: DNA damage & Cancer. The author has an hindex of 158, co-authored 506 publications receiving 129010 citations. Previous affiliations of Bruce N. Ames include Boston Children's Hospital & Laboratory of Molecular Biology.
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Journal ArticleDOI
Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning.
Maria B. Kadiiska,Beth C. Gladen,Donna D. Baird,LeRae Graham,Carol E. Parker,Bruce N. Ames,Samar Basu,Garret A. FitzGerald,John A. Lawson,Lawrence J. Marnett,Jason D. Morrow,D.M. Murray,J. Plastaras,L. J. Roberts,J. Rokach,Mark K. Shigenaga,J. Sun,Patrick B. Walter,Kenneth B. Tomer,J.C. Barrett,Ronald P. Mason +20 more
TL;DR: Results provide evidence that these lipid-degradation products primarily constitute markers of oxidative stress.
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Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications
TL;DR: It is shown that repression of the histidine operon is correlated directly with the concentration of charged histidyl-tRNAHis in vivo and not with the ratio of charged to uncharged or the absolute amount of uncharged tRNAHis.
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Antioxidant status and indexes of oxidative stress during consecutive days of exercise.
TL;DR: Observed increases in GSH oxidation indicate the presence of oxidant stress during prolonged submaximal exercise and similar redox changes on consecutive days of exercise, with recovery to preexercise values within 15 min, indicate no evidence of persistent or cumulative exercise effects on blood glutathione redox status.
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γ-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis
TL;DR: It is demonstrated that gammaT and mixed vitamin E forms induce cell death by interrupting the de novo sphingolipid pathway in a prostate cancer cell line, which may be valuable as anticancer agents.
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Transport of antibiotics and metabolite analogs by systems under cyclic AMP control: positive selection of Salmonella typhimurium cya and crp mutants.
M D Alper,Bruce N. Ames +1 more
TL;DR: It is proposed that these antibiotics and analogs entering the bacteria through transport systems normally used for transporting fuel/carbon sources are accomplished because of a structural similarity between the antibiotic and the natural substrate of the particular transport system involved.