B
Bruce Tidor
Researcher at Massachusetts Institute of Technology
Publications - 180
Citations - 19350
Bruce Tidor is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Protease & Binding site. The author has an hindex of 60, co-authored 179 publications receiving 17680 citations. Previous affiliations of Bruce Tidor include National University of Singapore & Harvard University.
Papers
More filters
Journal ArticleDOI
Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin.
Lu Huang,Catherine Qiurong Pan,Baowen Li,Lisa Tucker-Kellogg,Bruce Tidor,Bruce Tidor,Bruce Tidor,Yu Zong Chen,Boon Chuan Low +8 more
TL;DR: A detailed and quantitative demonstration of how regulators and scaffolds can collaborate to fine-tune the ligand-dependent sensitivity of EGFR endocytosis and ERK activation which could underlie differences during normal physiology, disease states and drug responses is provided.
Book ChapterDOI
Increased flexibility in genetic algorithms: the use of variable boltzmann selective pressure to control propagation
Michael de la Maza,Bruce Tidor +1 more
TL;DR: Modifiable Boltzmann selective pressure is investigated as a tool to control variability in optimizations using genetic algorithms and is compared to a genetic algorithm lacking this control feature and is shown to exhibit superior convergence properties on a small set of test problems.
Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution
Boyang Zhao,Raja Srinivas,Pau Creixell Morera,Justin R. Pritchard,Bruce Tidor,Douglas A. Lauffenburger,Michael T. Hemann +6 more
Journal ArticleDOI
Rational design of thiolase substrate specificity for metabolic engineering applications.
TL;DR: This study presents a model‐guided, rational design study of ordered substrate binding applied to two biosynthetic thiolases, with the goal of increasing the ratio of C6/C4 products formed by the 3HA pathway, 3‐hydroxy‐hexanoic acid and 3‐Hydroxybutyric acid.
Boltzmannn Weighted Selection Improves Performance of Genetic Algorithms
Michael de la Maza,Bruce Tidor +1 more
TL;DR: Modifiable Boltzmann selective pressure is investigated as a tool to control variability in optimizations using genetic algorithms and is compared to a genetic algorithm lacking this control feature and is shown to exhibit superior convergence properties on a small set of test problems.