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Bruce Tidor
Researcher at Massachusetts Institute of Technology
Publications - 180
Citations - 19350
Bruce Tidor is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Protease & Binding site. The author has an hindex of 60, co-authored 179 publications receiving 17680 citations. Previous affiliations of Bruce Tidor include National University of Singapore & Harvard University.
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Protein Stabilization by Removal of Unsatisfied Polar Groups: Computational Approaches and Experimental Tests†
TL;DR: The Arc variant (MYL-NA29/SA44/EA48) in which the entire six-residue polar network is replaced by nonpolar groups is 5.1 kcal/mol of dimer more stable than wild type, indicating that the strategy of replacing buried or partially buried charged and polar side chains with hydrophobic residues can lead to substantial stabilization.
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Computation of electrostatic complements to proteins: a case of charge stabilized binding.
TL;DR: A novel method for computing ligand‐charge distributions that optimize the tradeoff between ligand desolvation penalty and favorable interactions with a binding site has been applied to a model for barnase, resulting in a ligand-charge distribution with a favorable electrostatic contribution to binding.
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Inelastic neutron scattering analysis of picosecond internal protein dynamics: Comparison of harmonic theory with experiment☆
TL;DR: The fact that the inelastic neutron scattering measurements can distinguish between the two theoretical models makes clear their utility for the analysis of protein dynamics.
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Efficient calculation of molecular configurational entropies using an information theoretic approximation.
TL;DR: In this article, the authors proposed a new method to compute molecular entropies based on the maximum information spanning tree (MIST) approximation that they have previously developed, which is guaranteed to bound the entropy.
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Inelastic neutron scattering analysis of low-frequency motions in proteins : harmonic and damped harmonic models of bovine pancreatic tryspin inhibitor
TL;DR: In this article, inelastic neutron scattering spectra are calculated from harmonic and damped harmonic models of the internal dynamics of a small protein, the bovine pancreatic trypsin inhibitor (BPTI).