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Bruce Tidor
Researcher at Massachusetts Institute of Technology
Publications - 180
Citations - 19350
Bruce Tidor is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Protease & Binding site. The author has an hindex of 60, co-authored 179 publications receiving 17680 citations. Previous affiliations of Bruce Tidor include National University of Singapore & Harvard University.
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Journal ArticleDOI
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control
Effendi Leonard,Parayil Kumaran Ajikumar,Kelly M. Thayer,Wen-Hai Xiao,Jeffrey D. Mo,Bruce Tidor,Gregory Stephanopoulos,Kristala L. J. Prather +7 more
TL;DR: The present study highlights the importance of engineering proteins along with pathways as a key strategy in achieving microbial biosynthesis and overproduction of pharmaceutical and chemical products.
Journal ArticleDOI
The contribution of vibrational entropy to molecular association. The dimerization of insulin.
Bruce Tidor,Martin Karplus +1 more
TL;DR: The approach of Chandler and Pratt is used to provide a statistical mechanical formulation for the connection between the gas-phase and solution binding free energies, making possible a clear separation of the vibrational contribution to theGas-phase binding enthalpy and entropy from the solvation terms.
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De novo determination of peptide structure with solid-state magic-angle spinning NMR spectroscopy.
Chad M. Rienstra,Lisa Tucker-Kellogg,Christopher P. Jaroniec,M. Hohwy,Bernd Reif,Michael T. McMahon,Bruce Tidor,Tomás Lozano-Pérez,Robert G. Griffin +8 more
TL;DR: The peptide's structure was calculated by means of simulated annealing and a newly developed protocol that ensures that all of conformational space, consistent with the structural constraints, is searched completely, resulting in a high-quality structure that has thus far not been amenable to single-crystal diffraction studies.
A Post-Synaptic Scaffold at the Origin of the Animal
Kingdom Sakarya,Kathryn A. Armstrong,Maja Adamska,Marcin Adamski,I-Fan Wang,Bruce Tidor,Bernard M. Degnan,H Todd,Kenneth S. Kosik +8 more
TL;DR: Highly conserved protein interaction motifs and co-expression in sponges of multiple proteins whose homologs interact in eumetazoan synapses indicate that a complex protein scaffold was present at the origin of animals, perhaps predating nervous systems.
Journal ArticleDOI
A Post-Synaptic Scaffold at the Origin of the Animal Kingdom
Onur Sakarya,Kathryn A. Armstrong,Maja Adamska,Marcin Adamski,I-Fan Wang,Bruce Tidor,Bernard M. Degnan,Todd H. Oakley,Kenneth S. Kosik +8 more
TL;DR: In this paper, the evolution of complex subcellular structures such as the synapse requires the assembly of multiple proteins, each conferring added functionality to the integrated structure, and tracking the early evolution of synapses has not been possible without genomic information from the earliest branching animals.