B
Bruna Pucci
Researcher at Thomas Jefferson University
Publications - 35
Citations - 2146
Bruna Pucci is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 20, co-authored 35 publications receiving 1904 citations. Previous affiliations of Bruna Pucci include Sapienza University of Rome.
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Journal ArticleDOI
Cell cycle and apoptosis.
TL;DR: Translating the knowledge gained by studying the connection between cell death and cell proliferation may aid in identifying novel therapies to circumvent disease progression or improve clinical outcome.
Journal ArticleDOI
SIRT5 regulation of ammonia-induced autophagy and mitophagy
Lucia Polletta,Enza Vernucci,Ilaria Carnevale,Tania Arcangeli,Dante Rotili,Silvia Palmerio,Clemens Steegborn,Theresa Nowak,Mike Schutkowski,Laura Pellegrini,Luigi Sansone,Lidia Villanova,Alessandra Runci,Bruna Pucci,Emanuela Morgante,Massimo Fini,Antonello Mai,Matteo Antonio Russo,Marco Tafani +18 more
TL;DR: The role of SIRT5 in nonliver cells is to regulate ammonia production and ammonia-induced autophagy by regulating glutamine metabolism.
Journal ArticleDOI
Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction.
Gabriella Marfe,Marco Tafani,Manuela Indelicato,Paola Sinibaldi-Salimei,Valentina Reali,Bruna Pucci,Massimo Fini,Matteo Antonio Russo +7 more
TL;DR: The study shows that the oxidative stress induced by kaempferol in K562 and U937 cell lines causes the inactivation of Akt and the activation of the mitochondrial phase of the apoptotic program with an increase of Bax and SIRT3, decrease of Bcl‐2, release of cytochrome c, caspase‐3 activation, and cell death.
Journal ArticleDOI
Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-κB
Marco Tafani,Luana Schito,Laura Pellegrini,Lidia Villanova,Gabriella Marfe,Tahira Anwar,Roberta De Rosa,Manuela Indelicato,Massimo Fini,Bruna Pucci,Matteo Antonio Russo +10 more
TL;DR: Results show that, hypoxia can upregulate expression levels of membrane receptors that, by binding extracellular molecules eventually released by necrotic cells, contribute to the increased invasiveness of transformed tumor cells.
Journal Article
Frequent loss of expression of the cyclin-dependent kinase inhibitor p27 in epithelial ovarian cancer.
Valeria Masciullo,Alessandro Sgambato,Carmen Pacilio,Bruna Pucci,Gabriella Ferrandina,Juan P. Palazzo,Arnaldo Carbone,Achille Cittadini,Salvatore Mancuso,Giovanni Scambia,Antonio Giordano +10 more
TL;DR: Data indicate that loss of p27 is a frequent event in ovarian carcinomas as compared with LMP tumors, suggesting that these tumor types may have different pathogenesis.