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Bruno Linclau
Researcher at University of Southampton
Publications - 128
Citations - 2137
Bruno Linclau is an academic researcher from University of Southampton. The author has contributed to research in topics: Enantioselective synthesis & Lipophilicity. The author has an hindex of 25, co-authored 126 publications receiving 1810 citations. Previous affiliations of Bruno Linclau include Centre national de la recherche scientifique & La Jolla Institute for Allergy and Immunology.
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Journal ArticleDOI
Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non‐UV‐Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method
Bruno Linclau,Zhong Wang,Guillaume Compain,Vincent Paumelle,Clement Q. Fontenelle,Neil J. Wells,Alexander C. Weymouth-Wilson +6 more
TL;DR: A new variation of the shake‐flask log P determination method is presented, enabling the measurement of log’P for fluorinated compounds with or without UV activity regardless of whether they are hydrophilic or lipophilic.
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An Unexpected and Significantly Lower Hydrogen‐Bond‐Donating Capacity of Fluorohydrins Compared to Nonfluorinated Alcohols
Jérôme Graton,Zhong Wang,Anne-Marie Brossard,Daniela Gonçalves Monteiro,Jean-Yves Le Questel,Bruno Linclau +5 more
TL;DR: The success of fluorination in improving molecular properties over a wide range of applications (including pharmaceuticals, agrochemicals,2 materials,3 and crystal engineering) has been remarkable.
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Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase from Mycobacterium tuberculosis Using Substrate and Tetrafluorinated Substrate Analogues
Karin E. van Straaten,Jijin R. A. Kuttiyatveetil,Charlotte M. Sevrain,Sydney A. Villaume,Jesús Jiménez-Barbero,Jesús Jiménez-Barbero,Bruno Linclau,Stéphane P. Vincent,David A. R. Sanders +8 more
TL;DR: The complex structure of MtUGM with UDP-F4-Galf reveals the first detailed insight into how the furanose moiety binds to UGM, and confirmed that the furanoside adopts a high-energy conformation within the catalytic pocket.
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Invariant NKT Cells Promote CD8+ Cytotoxic T Cell Responses by Inducing CD70 Expression on Dendritic Cells
Vadim Y. Taraban,Sonya Martin,Kathrine E. Attfield,Martin J. Glennie,Tim Elliott,Dirk Elewaut,Serge Van Calenbergh,Bruno Linclau,Aymen Al-Shamkhani +8 more
TL;DR: It is demonstrated that injection of α-galactosylceramide triggers CD70 expression on splenic T cell zone dendritic cells and that this is dependent on CD40 signaling, which defines a key role for CD70 in linking the innate response of iNKT cells to the activation of CD8+ T cells.
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6′-Derivatised α-GalCer Analogues Capable of Inducing Strong CD1d-Mediated Th1-Biased NKT Cell Responses in Mice
Matthias Trappeniers,Katrien Van Beneden,Tine Decruy,Ulrik Hillaert,Bruno Linclau,Dirk Elewaut,Serge Van Calenbergh +6 more
TL;DR: The synthesis of 6′-modified α-GalCer analogues with an intact phytoceramide moiety that are capable to skew the cytokine release profile to Th1, while maintaining strong antigenic activity is described.