Showing papers by "Bryan Burmeister published in 2009"
TL;DR: Early experience with cetuximab/RT has demonstrated a higher rate of toxicity compared with the recently reported randomised trial, resulting in low treatment compliance and delays in completing RT.
114 citations
TL;DR: This is the first completed study to assess the effects of RT on regional recurrence, survival, morbidity and quality of life (QOL) in patients with isolated regionalRecurrence of melanoma considered to be at high risk of further regional Recurrence after lymphadenectomy.
Abstract: LBA9084 Background: Adjuvant radiotherapy (RT) is an option for patients with isolated regional recurrence of melanoma considered to be at high risk of further regional recurrence after lymphadenectomy. This is the first completed study to assess the effects of RT on regional recurrence, survival, morbidity and quality of life (QOL) in these patients. Methods: Multicenter randomized study of patients with isolated regional recurrence at increased risk (>25%) of regional recurrence. Eligibile patients included ≥1 parotid, ≥ 2 cervical or axillary or ≥ 3 groin nodes or extra nodal spread of tumor or maximum metastatic node diameter ≥3cm in neck or axilla or ≥4cm in the groin. Patients were randomized to observation or regional nodal basin RT (48Gy in 20 fractions) after lymphadenectomy. Regional recurrence was the primary end point and morbidity, QOL, patterns of relapse, disease free and overall survival were secondary end points. The target sample size was 220 patients, which would enable a difference in ...
42 citations
TL;DR: In this paper, the authors present a survey of the state-of-the-art cancer centers in Australia, including the Peter MacCallum Cancer Centre, Melbourne, Australia, Sydney Melanoma Unit, Sydney, Australia.
Abstract: B. Burmeister, M. Henderson, J. Thompson, R. Fisher, J. Di Iulio, M. Smithers, A. Hong, S. Carruthers, H. Hoekstra, J. Ainslie Princess Alexandra Hospital, Brisbane, Australia, Peter MacCallum Cancer Centre, Melbourne, Australia, Sydney Melanoma Unit, Sydney, Australia, Biostatistical and Clinical Trials Centre, Melbourne, Australia, Biostatisitcal and Clinical Trials Centre, Melbourne, Australia, Royal Prince Alfred Hospital, Sydney, Australia, Royal Adelaide Hospital, Adelaide, Australia, Groningen University, Groningen, The Netherlands
19 citations
TL;DR: Although weekly oxaliplatin in combination with infusional 5 fluorouracil produces durable remissions in esophageal cancer, the regimen used in this trial was not acceptable for routine use.
Abstract: Summary Background Chemoradiation therapy using regimens containing cisplatin and 5-fluorouracil are most commonly used for inoperable cancer of the esophagus. Cisplatin is relatively toxic and is not suitable for many patients. Little data exists using platinum analogues together with protracted infusion 5-fluorouracil and radiation therapy in the curative setting. Methods Fourteen patients with localised oesophageal cancer suitable for curative chemoradiation therapy registered on the study. Chemotherapy consisted of 5-fluorouracil 225 mg/m2 daily throughout radiation therapy, with oxaliplatin 60 mg/m2 weekly. The radiation dose was 56 to 60 Gy in 28 to 30 fractions. Results The median age of the patients was 70.5 years. Therapy was associated with excessive grade 3 and 4 non-hematologic toxicity. There was one treatment related death. The median progression-free survival was 31.5 months and median overall survival 32.6 months. Six patients achieved a prolonged complete endoscopic and radiological response. Conclusions Although weekly oxaliplatin in combination with infusional 5 fluorouracil produces durable remissions in esophageal cancer, the regimen used in this trial was not acceptable for routine use. Future protocols should incorporate lower chemotherapy doses.
14 citations
Journal Article•
TL;DR: This dissertation aims to provide a history of Melanoma research in Australia and investigates the roots of the disease, as well as specific cases in Brisbane and Adelaide, which have had particular notoriety for having high mortality rates.
1 citations