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Bryce T McLelland
Researcher at University of California, Irvine
Publications - 9
Citations - 287
Bryce T McLelland is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Retina & Retinal. The author has an hindex of 5, co-authored 9 publications receiving 154 citations.
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Journal ArticleDOI
Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats
Bryce T McLelland,Bin Lin,Anuradha Mathur,Robert B. Aramant,Biju B. Thomas,Gabriel Nistor,Hans S. Keirstead,Magdalene J. Seiler +7 more
TL;DR: Data demonstrate that the transplantation of sheets dissected from hESC-derived retina organoids is a potential therapeutic method for restoring vision in advanced stages of RD.
Journal ArticleDOI
Vision Recovery and Connectivity by Fetal Retinal Sheet Transplantation in an Immunodeficient Retinal Degenerate Rat Model.
Magdalene J. Seiler,Robert E Lin,Bryce T McLelland,Anuradha Mathur,Bin Lin,Jaclyn Sigman,Alexander De Guzman,L. M. Kitzes,Robert B. Aramant,Biju B. Thomas +9 more
TL;DR: The data suggest that retinal sheet transplants integrate into the host retina of RD nude rats and recover significant visual function.
Journal ArticleDOI
Retina Organoid Transplants Develop Photoreceptors and Improve Visual Function in RCS Rats With RPE Dysfunction.
Bin Lin,Bryce T McLelland,Robert B. Aramant,Biju B. Thomas,Gabriel Nistor,Hans S. Keirstead,Magdalene J. Seiler +6 more
TL;DR: This study is the first to show that transplanted photoreceptors survive and function even with host's dysfunctional RPE, and suggests that transplantation of organoid sheets from stem cells may be a promising approach/therapeutic for blinding diseases.
Journal ArticleDOI
Sheets of human retinal progenitor transplants improve vision in rats with severe retinal degeneration.
TL;DR: It is shown that human fetal retinal sheets transplanted to the severely disturbed subretinal space of RD nude rats develop mature photoreceptors and other retinal cells, integrate with the host and induce vision improvement.
Journal ArticleDOI
Detailed Visual Cortical Responses Generated by Retinal Sheet Transplants in Rats with Severe Retinal Degeneration.
Andrzej T. Foik,Georgina A. Lean,Leo R. Scholl,Bryce T McLelland,Anuradha Mathur,Robert B. Aramant,Magdalene J. Seiler,David C. Lyon +7 more
TL;DR: Remarkably, transplants generated visual responses in cortex similar in quality to normal rats and preserved connectivity within visual cortex and the retinal relay from the lateral geniculate nucleus to visual cortex, supporting their potential application in curing vision loss associated with retinal degeneration.