Burong Hu

TL;DR: It is shown, consistent with biophysical modeling, that the kinetics of loss of clustered DNA lesions was substantially compromised in human fibroblasts, and difficulties associated with clustered DNA damage repair and checkpoint release before the completion of clusteredDNA damage repair appear to promote genome instability that may lead to carcinogenesis.

TL;DR: Both lindane and DMSO significantly suppressed the yield of DSBs in the cells of unirradiated bystander areas, which suggest that gap junctional intercellular communication and reactive oxygen species played important roles in the induction of the bystander effects, both in irradiated and unir Radiated bystanderser areas.

TL;DR: Findings enrich the complex relationships between miRNA and DNMTs in carcinogenesis and irradiation stress and sheds light on the potential combination of ionizing radiation and epigenetic regulation in prostate cancer therapy.

TL;DR: These are the first data to show the effects of radiation with varying linear energy transfer on a human vessel model, and it is shown that inhibition of vessel development or deterioration of mature vessels was not due to cell death by apoptosis even in the case of iron ions.

TL;DR: In situ visualization of DSBs can be used to assess radiation-induced extranuclear/extracellular effects soon after irradiation, and the in situ DSB assay may provide a means to evaluate the spatial effect on unirradiated cells that are located in the neighboring region of cells irradiated by α particles.