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Burtram C. Fielding
Researcher at University of the Western Cape
Publications - 62
Citations - 4556
Burtram C. Fielding is an academic researcher from University of the Western Cape. The author has contributed to research in topics: Coronavirus & Gene. The author has an hindex of 23, co-authored 56 publications receiving 3458 citations. Previous affiliations of Burtram C. Fielding include Institute of Molecular and Cell Biology.
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Coronavirus envelope protein: current knowledge
TL;DR: Data shows that E is involved in critical aspects of the viral life cycle and that CoVs lacking E make promising vaccine candidates, which can aid in the production of effective anti-coronaviral agents for both human CoVs and enzootic CoVs.
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The coronavirus nucleocapsid is a multifunctional protein
TL;DR: The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions.
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Overexpression of 7a, a Protein Specifically Encoded by the Severe Acute Respiratory Syndrome Coronavirus, Induces Apoptosis via a Caspase-Dependent Pathway
Yee-Joo Tan,Burtram C. Fielding,Phuay Yee Goh,Shuo Shen,Timothy H.P. Tan,Seng Gee Lim,Wanjin Hong +6 more
TL;DR: It is shown that the overexpression of 7a, but not of 3a or the viral structural proteins, nucleocapsid, membrane, and envelope, induces apoptosis.
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MERS-CoV: Understanding the Latest Human Coronavirus Threat
TL;DR: This review summarises the current understanding of MERS-CoV, with special reference to the genome structure; clinical features; diagnosis of infection; and treatment and vaccine development.
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Profiles of antibody responses against severe acute respiratory syndrome coronavirus recombinant proteins and their potential use as diagnostic markers
Yee-Joo Tan,Phuay Yee Goh,Burtram C. Fielding,Shuo Shen,Chih Fong Chou,Jian Lin Fu,Hoe Nam Leong,Yee Sin Leo,Eng Eong Ooi,Ai Ee Ling,Seng Gee Lim,Wanjin Hong +11 more
TL;DR: Results suggest that recombinant N, S, and U274 proteins may be used as antigens for the development of serological assays for SARS-CoV.