B
Byung-Hyun Park
Researcher at Chonbuk National University
Publications - 245
Citations - 7649
Byung-Hyun Park is an academic researcher from Chonbuk National University. The author has contributed to research in topics: Proinflammatory cytokine & Apoptosis. The author has an hindex of 42, co-authored 227 publications receiving 6430 citations. Previous affiliations of Byung-Hyun Park include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway
Ji-Hyun Lee,Mi-Young Song,Eun-Kyung Song,Eun Kyung Kim,Woo Sung Moon,Myung-Kwan Han,Jinwoo Park,Kang-Beom Kwon,Byung-Hyun Park +8 more
TL;DR: This study will provide valuable information not only into the mechanisms underlying β-cell destruction but also into the regulation of SIRT1 as a possible target to attenuate cytokine-inducedβ-cell damage.
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Rapid transformation of white adipocytes into fat-oxidizing machines
Lelio Orci,William S. Cook,Mariella Ravazzola,May-Yun Wang,Byung-Hyun Park,Roberto Montesano,Roger H Unger,Roger H Unger +7 more
TL;DR: Phosphorylation of both acetyl CoA carboxylase and AMP-activated protein kinase was increased, thus explaining the increase in fatty acid oxidation and the ability to transform adipocytes into unique fat-burning cells may suggest novel therapeutic strategies for obesity.
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Making insulin-deficient type 1 diabetic rodents thrive without insulin
TL;DR: It is suggested that leptin reverses the catabolic consequences of total lack of insulin, potentially by suppressing glucagon action on liver and enhancing the insulinomimetic actions of IGF-1 on skeletal muscle, and suggest strategies for making type 1 diabetes insulin-independent.
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Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Eun Jung Cha,Sang Jae Noh,Keun Sang Kwon,Chan Young Kim,Byung-Hyun Park,Ho Sung Park,Ho Lee,Myoung Ja Chung,Myoung Jae Kang,Dong Geun Lee,Woo Sung Moon,Kyu Yun Jang +11 more
TL;DR: This study shows that expression of DBC1 and SIRT1 is a significant prognostic indicator for gastric carcinoma patients and were independent prognostic factors significantly associated with overall survival and relapse-free survival.
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Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells.
Kang-Beom Kwon,Su-Jin Yoo,Do-Gon Ryu,Jeong-Yeh Yang,Hye-Won Rho,Jong-Suk Kim,Jin-Woo Park,Hyung-Rho Kim,Byung-Hyun Park +8 more
TL;DR: Results indicate that DADS-induced apoptosis is triggered by the generation of hydrogen peroxide, activation of caspase-3, degradation of PARP, and fragmentation of DNA.