Byungjin Hwang

TL;DR: The available scRNA-seq technologies and the strategies available to analyze the large quantities of data produced will impact both basic and medical science, from illuminating drug resistance in cancer to revealing the complex pathways of cell differentiation during development.

TL;DR: A genome editing strategy is developed using a cytidine deaminase fused with nickase Cas9 (nCas9) to specifically target endogenous interspersed repeat regions in mammalian cells to create genetic barcodes for fine-resolution mapping.

TL;DR: Collectively, mutational profile and adverse prognostic genes in Korean CLL were different from those of Caucasians, suggesting an ethnic difference, while profile of cytogenetic aberrations was similar to those of Caucasianians.

TL;DR: CRISPR-Cap is developed, a simple and scalable CRISpr-based method to enrich target regions of dsDNA, requiring only two short experimental procedures that can be completed within two hours, and can be used as an alternative to other widely used target-enrichment methods, which will broaden the scope of CRISPR applications to the field of target enrichment field.

TL;DR: This study confirmed the utility of genetic diagnosis of FH through WES through whole-exome sequencing and identified three novel causative mutations in Koreans that were validated by co-segregation in their relatives.