C.K. van Kalken

TL;DR: Immunohistochemical staining with a p110-specific monoclonal antibody showed that the molecule has a high expression in normal epithelial cells and tissues chronically exposed to xenobiotics and potentially toxic agents, such as bronchial cells, cells lining the intestines, and kidney tubules.

TL;DR: In this article, the authors investigated the tissue distribution of P-glycoprotein in normal and malignant human tissues, employing a routine immunoperoxidase technique, and found that P glycoprotein is strongly associated with multi-drug resistance to certain cytostatic drugs, including adriamycin, vincristine, and daunorubicin.

TL;DR: It is demonstrated that cell lines with a high expression of Pgp display a reduced accumulation of cortisol and an ATP-dependent outward transport of the hormone, and a physiological role of the protein in steroid handling by organs such as the adrenal is suggested.

TL;DR: A pivotal role of P-glycoprotein in physiology of various organs already in early phases of human development is suggested and may help to identify its physiologic substrates.

TL;DR: N/C ratio measurements may define a general Pgp-independent type of defense of mammalian cells against certain anticancer agents which may precede Pgp expression in early doxorubicin resistance.