R.J. Scheper

TL;DR: The apical localization in the epithelium of the small intestine and colon indicates a possible role of BCRP in the regulation of the uptake of p.o. delivered B CRP substrates by back-transport of substrate drugs entering from the gut lumen and is consistent with the hypothesis of a protective role ofBCRP for the fetus.

TL;DR: In this paper, the authors identified three new homologues of MRP1, the gene encoding the multidrug resistanceassociated protein, and cMOAT (or MRP2 ), the canalicular multispecific organic anion transporter gene.

TL;DR: MRP3 is an organic anion and multidrug transporter, like the GS-X pumps MRP1 and MRP2, and in Madin-Darby canine kidney II cells, MRP3 routes to the basolateral membrane and mediates transport of the organicAnion S-(2,4-dinitrophenyl-)glutathione toward the basoliateral side of the monolayer.

TL;DR: It is demonstrated that overexpression of the MRP gene in human cancer cells increases the ATP-dependent glutathione S-conjugate carrier activity in plasma membrane vesicles isolated from these cells, suggesting that MRP can cause multidrug resistance by promoting the export of drug modification products from cells.

TL;DR: The human homologue of rat cmoat, human cMOAT, is isolated and analyzed the corresponding cDNA from fibroblasts of a DJS patient for mutations, showing that a mutation in this gene is the cause of DJS.