C
C. Katlama
Researcher at Centre national de la recherche scientifique
Publications - 6
Citations - 2091
C. Katlama is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Antigen & CD8. The author has an hindex of 4, co-authored 6 publications receiving 2061 citations.
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Journal ArticleDOI
Positive Effects of Combined Antiretroviral Therapy on CD4+ T Cell Homeostasis and Function in Advanced HIV Disease
Brigitte Autran,Guislaine Carcelain,T.S. Li,Catherine Blanc,Dominique Mathez,R. Tubiana,C. Katlama,Patrice Debré,Jacques Leibowitch +8 more
TL;DR: In this article, a three-phase T cell reconstitution was demonstrated after HAART, with an early rise of memory CD4(+) cells, a reduction in T cell activation correlated to the decreasing retroviral activity together with an improved CD4+ T cell reactivity to recall antigens.
Journal Article
T cell receptor gamma/delta+ lymphocyte subsets during HIV infection.
TL;DR: Data suggest a conservation of the Ti-Gamma A+ subset during HIV infection, contrasting with an increase of the delta-TcS1+, Ti-gamma A- fraction in some cases.
Journal ArticleDOI
CD8hi+CD57+ T lymphocytes are enriched in antigen-specific T cells capable of down-modulating cytotoxic activity.
Lucile Mollet,Behazine Sadat-Sowti,J. Duntze,V Leblond,F. Bergeron,Vincent Calvez,C. Katlama,Patrice Debré,Brigitte Autran +8 more
TL;DR: Data suggest that CD8hi+CD57+ cells represent a terminal differentiation state of activated effector cytotoxic T lymphocytes which are enriched in antigen-specific T cells and down-modulate their own cytolytic potential, thus participating in a negative control of effector cell functions during persistent viral infections or transplantations.
Journal Article
Antiretroviral therapy and immune reconstitution
G. Carcelain,T.S. Li,M. Renaud,C. Blanc,R. Tubiana,Calvez,Jacques Leibowitch,Patrice Debré,H. Agut,C. Katlama,Brigitte Autran +10 more
TL;DR: HAART by reducing the virus burden is unable to restore immunity against HIV itself, except when introduced at the very early stage after virus inoculation, and positive effects can be obtained at late stages of the disease even when the patients have been heavily pre-treated.
Journal ArticleDOI
Traitements anti-rétroviraux et reconstitution immune
G. Carcelain,T.S. Li,M. Renaud,C. Blanc,R. Tubiana,V. Calvez,Jacques Leibowitch,Patrice Debré,H. Agut,C. Katlama,Brigitte Autran +10 more
TL;DR: La restauration d’une immunite efficace contre les pathogenes opportunistes et contre le VIH lui-meme depend de notre capacite a maintenir au long cours un controle efficace de the replication virale and constitue desormais l’un des objectifs essentiels des nouveaux traitements antiretroviraux.