B
Behazine Sadat-Sowti
Researcher at Centre national de la recherche scientifique
Publications - 11
Citations - 648
Behazine Sadat-Sowti is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: CD8 & Cytotoxic T cell. The author has an hindex of 9, co-authored 11 publications receiving 646 citations.
Papers
More filters
Journal ArticleDOI
Oligoclonal expansion of CD8+ CD57+ T cells with restricted T-cell receptor beta chain variability after bone marrow transplantation
Guy Gorochov,Patrice Debré,Véronique Leblond,Behazine Sadat-Sowti,François Sigaux,Brigitte Autran +5 more
TL;DR: Such an oligoclonal expansion of CD8+57+ cells, using a restricted set of the V beta gene families, may result from a specific TCR stimulation of a limited number of T-cell clones in BMT recipients.
Journal ArticleDOI
A soluble factor released by CD8+CD57+ lymphocytes from bone marrow transplanted patients inhibits cell-mediated cytolysis.
Brigitte Autran,Véronique Leblond,Behazine Sadat-Sowti,Evelyne Lefranc,Pierre Got,Laurent Sutton,J. L. Binet,Patrice Debré +7 more
TL;DR: Preliminary characterization suggests that the CD8+CD57+ cells' inhibitory activity is mediated by a low molecular weight, glycosylated factor as indicated by its less than 1S coefficient of sedimentation and its binding to concanavalin A lectin.
Journal ArticleDOI
Carboxyl-terminal and central regions of human immunodeficiency virus-1 NEF recognized by cytotoxic T lymphocytes from lymphoid organs. An in vitro limiting dilution analysis.
Fabienne Hadida,A Parrot,M P Kieny,Behazine Sadat-Sowti,Charles Mayaud,Patrice Debré,Brigitte Autran +6 more
TL;DR: In this article, the carboxyl-terminal domain of NEF was found to be conserved among several HIV strains, and the primary NEF-specific CTL responses were further characterized by epitope mapping.
Journal ArticleDOI
A lectin-binding soluble factor released by CD8+CD57+ lymphocytes from AIDS patients inhibits T cell cytotoxicity.
Behazine Sadat-Sowti,Patrice Debré,T Idziorek,Jean-Marcel Guillon,Fabienne Hadida,E Okzenhendler,Christine Katlama,Charles Mayaud,Brigitte Autran +8 more
TL;DR: CD8+CD57+ T cells, expanded in peripheral blood lymphocytes of AIDS patients, inhibit the effector phase of HLA‐specific cytotoxic T lymphocytes, natural killer and lymphocyte‐activated killer cells in a 4‐h chromium‐release assay.
Journal ArticleDOI
CD8hi+CD57+ T lymphocytes are enriched in antigen-specific T cells capable of down-modulating cytotoxic activity.
Lucile Mollet,Behazine Sadat-Sowti,J. Duntze,V Leblond,F. Bergeron,Vincent Calvez,C. Katlama,Patrice Debré,Brigitte Autran +8 more
TL;DR: Data suggest that CD8hi+CD57+ cells represent a terminal differentiation state of activated effector cytotoxic T lymphocytes which are enriched in antigen-specific T cells and down-modulate their own cytolytic potential, thus participating in a negative control of effector cell functions during persistent viral infections or transplantations.