CA : A Cancer Journal for Clinicians

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Food, Nutrition, Physical Activity, and the Prevention of Cancer : a Global Perspective : 食物、栄養、身体活動とがんの予防 : 世界的展望(後篇)

A review on anticancer potential of bioactive heterocycle quinoline.

Synthesis, characterization and biological evaluation of some thiourea derivatives bearing benzothiazole moiety as potential antimicrobial and anticancer agents.

A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry.

Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy.

Epigenetics in cancer: Fundamentals and Beyond

Synthesis and antitumor activity of optically active thiourea and their 2-aminobenzothiazole derivatives: a novel class of anticancer agents.

The radio-protective ability of sesamol (SM) at various doses viz., 0, 10, 25, 40, 50, 70 and 100mg/kg bw, administered intraperitoneally 30min prior to 9.5Gy whole-body gamma-irradiation was studied in Swiss albino mice. Radiation toxicity and mortality were observed during a period of 30 days and the percentage mortality was calculated. SM pretreatment with 50mg/kg bw was found to be the most effective dose in maintaining body weight and in reducing the percentage mortality, while 100mg/kg bw was found to be more effective in maintaining the spleen index and in stimulation of endogenous spleen colony-forming units. Pretreatment with SM (50mg/kg bw) in mice irradiated with 15Gy significantly reduced dead, inflammatory, mitotic and goblet cells in irradiated jejunum. SM at 50mg/kg bw also increased crypt cells, maintained villus height, and prevented mucosal erosion. Nuclear enlargement in epithelial cells was found less in SM-treated mice compared with the irradiated control. The radiation-induced decrease in endogenous antioxidant enzymes (GSH, GST, catalase) and the increase in lipid peroxidation were also reduced by pretreatment with SM [50 and 100mg/kg bw] at all monitored post-irradiation intervals. There was no protection at a dose less than 25mg/kg bw.

Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice.

Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells.

C. Mallikarjuna Rao

Papers

Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy.

Epigenetics in cancer: Fundamentals and Beyond

Synthesis and antitumor activity of optically active thiourea and their 2-aminobenzothiazole derivatives: a novel class of anticancer agents.

Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice.

Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells.