Polysaccharide hydrogels for modified release formulations.

While the peptide and protein therapeutic market has developed significantly in the past decades, delivery has limited their use. Although oral delivery is preferred, most are currently delivered intravenously or subcutaneously due to degradation and limited absorption in the gastrointestinal tract. Therefore, absorption enhancers, enzyme inhibitors, carrier systems and stability enhancers are being studied to facilitate oral peptide delivery. Additionally, transdermal peptide delivery avoids the issues of the gastrointestinal tract, but also faces absorption limitations. Due to proteases, opsonization and agglutination, free peptides are not systemically stable without modifications. This review discusses oral and transdermal peptide drug delivery, focusing on barriers and solutions to absorption and stability issues. Methods to increase systemic stability and site-specific delivery are also discussed.

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Basics and recent advances in peptide and protein drug delivery.

Nanostructured metal–organic frameworks and their bio-related applications

Alginate microparticles as oral colon drug delivery device: A review

Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: a concise overview.

Skin as an important site of drug application for both local and systemic effects. However in skin, the stratum corneum is the main barrier for drug penetration. Penetration enhancement technology is a challenging development that would increase the number of drugs available for transdermal administration. The permeation of drug through skin can be enhanced by both chemical penetration enhancement and physical methods. In this review, we have discussed the chemical penetration enhancement technology for transdermal drug delivery as well as the probable mechanisms of action.

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Chemical Penetration Enhancers for Transdermal Drug Delivery Systems

Gum ghatti: A promising polysaccharide for pharmaceutical applications

Furosemide-loaded calcium alginate (ALG), calcium alginate-polyethyleneimine (ALG-PEI) and alginate-coated ALG-PEI (ALG-PEI-ALG) beads were prepared by ionotropic/polyelectrolyte complexation method to achieve controlled release of the drug. Effects of several formulation factors on the characteristics of the beads were investigated. Although variation in formulation factors did not influence the drug-loading efficiency (DLE) of ALG beads, rapid release of the drug in simulated intestinal fluid (SIF) could not be prevented. PEI treatment of ALG beads, however, prolonged the drug release considerably. Ionic interaction, as appeared from FTIR studies, between alginate and PEI led to the formation of polyelectrolyte complex membrane, the thickness of which was dependent on the conditions of PEI treatment as demonstrated by scanning electron microscopy (SEM). The membrane acted as a physical barrier to drug release from ALG-PEI beads. Alginate coating of ALG-PEI beads further prolonged the release of the drug by increasing membrane thickness and reducing swelling of the beads possibly by blocking the surface pores. Differential scanning calorimetry (DSC) study indicated that drug was not degraded by PEI treatment. The release data from ALG-PEI beads showed a good fit in power law expression, whereas the release data from ALG-PEI-ALG beads were found to fit in modified power law expression, and the mechanism of drug release changed from super case II transport to nearly Fickian transport, depending on the degree of gelation and formation of polyelectrolyte complex membrane.

Alginate-coated alginate-polyethyleneimine beads for prolonged release of furosemide in simulated intestinal fluid

The objective of the present investigation was to formulate curcumin loaded fish scale collagen (FSC)-hydroxypropyl methyl cellulose (HPMC K100) nanogel (CNG) for wound healing application. The cur...

C. Mallikarjuna Setty

Papers

Chemical Penetration Enhancers for Transdermal Drug Delivery Systems

Gum ghatti: A promising polysaccharide for pharmaceutical applications

Alginate-coated alginate-polyethyleneimine beads for prolonged release of furosemide in simulated intestinal fluid

Curcumin loaded fish scale collagen-HPMC nanogel for wound healing application: Ex-vivo and In-vivo evaluation

Hydrolyzed polyacrylamide grafted maize starch based microbeads: application in pH responsive drug delivery.