C
C Roskelley
Publications - 9
Citations - 6701
C Roskelley is an academic researcher. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 1, co-authored 1 publications receiving 6215 citations.
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Journal ArticleDOI
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
Goberdhan P. Dimri,X Lee,G Basile,Meileen Acosta,G Scott,C Roskelley,E E Medrano,Maarten H.K. Linskens,Ivica Rubelj,Olivia M. Pereira-Smith +9 more
TL;DR: It is shown that several human cells express a beta-galactosidase, histochemically detectable at pH 6, upon senescence in culture, which provides in situ evidence that senescent cells may exist and accumulate with age in vivo.
Journal ArticleDOI
Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models
Diana Canals Hernaez,Michael R. Hughes,Yicong Li,Ilaria Mainero Rocca,Pamela Dean,Julyanne Brassard,Erin M. Bell,Ismael Samudio,Anne-Marie Mes-Masson,Yoshiki Narimatsu,Henrik Clausen,Ola Blixt,C Roskelley,Kelly M. McNagny +13 more
TL;DR: PODO447-ADCs are revealed as exquisitely tumor-specific and highly efficacious immunotherapeutic reagents for the targeting of human tumors and exhibits the appropriate characteristics for further development as a targeted clinical immunotherapy.
Journal ArticleDOI
Antibody-Drug Conjugates Targeting Tumor-Specific Mucin Glycoepitopes.
TL;DR: In this article , the authors describe three types of glycoepitopes that are recognized by monoclonal antibodies and serve as ideal scaffolds for ADC; glycan-only, glycopeptide and shielded-peptide glycoprotein.
Journal ArticleDOI
A tumor-restricted glycoepitope of podocalyxin correlates with immune evasion in high-grade serous ovarian carcinoma.
Julyanne Brassard,Diana Canals Hernaez,Michael R. Hughes,Katy Milne,Pamela Dean,Mary Warren,Kevin Zhang,Allyson C. Banville,Julian Smazynski,David Bond,Brad H. Nelson,C Roskelley,Kelly M. McNagny +12 more
TL;DR: In this article , the PODO447-antibody-drug conjugate (ADC) was used to identify a tumor-restricted glycoform of Podxl not expressed on normal tissue.
Book ChapterDOI
Modeling Collective Invasion and Single-Cell Mesenchymal Invasion in Three-Dimensional Matrigel-Collagen I Cultures.
TL;DR: This three-dimensional culture assay utilizes the features of Matrigel and Collagen I to mimic the laminin-rich basement membrane and the stiff, fibrillarCollagen I tumor microenvironment allowing for spheroid invasion to be assessed at the interface between these two matrix components.