K
Kelly M. McNagny
Researcher at University of British Columbia
Publications - 180
Citations - 12448
Kelly M. McNagny is an academic researcher from University of British Columbia. The author has contributed to research in topics: Podocalyxin & CD34. The author has an hindex of 50, co-authored 160 publications receiving 10718 citations. Previous affiliations of Kelly M. McNagny include Basel Institute for Immunology & University of Calgary.
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Journal ArticleDOI
Early infancy microbial and metabolic alterations affect risk of childhood asthma
Marie-Claire Arrieta,Leah T. Stiemsma,Pedro A. Dimitriu,Lisa Thorson,Shannon L. Russell,Sophie Yurist-Doutsch,Boris Kuzeljevic,Matthew J. Gold,Heidi Britton,Diana L. Lefebvre,Padmaja Subbarao,Piush J. Mandhane,Allan B. Becker,Kelly M. McNagny,Malcolm R. Sears,Tobias R. Kollmann,William W. Mohn,Stuart E. Turvey,B. Brett Finlay +18 more
TL;DR: It is reported in a longitudinal human study that infants at risk of asthma have transient gut microbial dysbiosis during the first 100 days of life, and certain bacterial genera were decreased in these children, suggesting a potential causative role of the loss of these microbes.
Journal ArticleDOI
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
Bahareh Ajami,Jami Bennett,Charles Krieger,Charles Krieger,Kelly M. McNagny,Fabio M.V. Rossi +5 more
TL;DR: It is found that, although microglia can enter the cell cycle and return to quiescence following remission, recruited monocytes vanish, and therefore do not ultimately contribute to the resident microglial pool.
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Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation.
Timotheus Y.F. Halim,Catherine A. Steer,Laura Mathä,Matthew J. Gold,Itziar Martinez-Gonzalez,Kelly M. McNagny,Andrew N. J. McKenzie,Fumio Takei,Fumio Takei +8 more
TL;DR: It is shown that group 2 innate lymphoid cells (ILC2s) are required to mount a robust Th2 cell response to the protease-allergen papain, suggesting a common pathway in the initiation of Th 2 cell responses to allergen.
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Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma
Shannon L. Russell,Matthew J. Gold,Martin Hartmann,Benjamin P. Willing,Lisa Thorson,Marta Wlodarska,Navkiran Gill,Marie-Renée Blanchet,William W. Mohn,Kelly M. McNagny,B. Brett Finlay +10 more
TL;DR: Data support a neonatal, microbiota‐driven, specific increase in susceptibility to experimental murine allergic asthma, consistent with the ‘hygiene hypothesis’.
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Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.
Benjamin S. Freedman,Craig R. Brooks,Albert Q. Lam,Albert Q. Lam,Hongxia Fu,Ryuji Morizane,Vishesh Agrawal,Abdelaziz F. Saad,Michelle Li,Michelle Li,Michael R. Hughes,Ryan Vander Werff,Derek T. Peters,Derek T. Peters,Junjie Lu,Anna Baccei,Andrew M. Siedlecki,M. Todd Valerius,M. Todd Valerius,Kiran Musunuru,Kiran Musunuru,Kelly M. McNagny,Theodore I. Steinman,Theodore I. Steinman,Jing Zhou,Jing Zhou,Paul H. Lerou,Paul H. Lerou,Joseph V. Bonventre,Joseph V. Bonventre +29 more
TL;DR: It is shown that hPSC-KCs self-organize into kidney organoids that functionally recapitulate tissue-specific epithelial physiology, including disease phenotypes after genome editing, establishing a reproducible, versatile three-dimensional framework for human epithelial disease modelling and regenerative medicine applications.