C
C. Shun Wong
Researcher at Sunnybrook Health Sciences Centre
Publications - 74
Citations - 3897
C. Shun Wong is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Radiation therapy & Spinal cord. The author has an hindex of 34, co-authored 70 publications receiving 3527 citations. Previous affiliations of C. Shun Wong include Ontario Institute for Cancer Research & University of Toronto.
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Journal ArticleDOI
Mechanisms of radiation injury to the central nervous system: implications for neuroprotection.
TL;DR: A focus is on apoptotic cell death, and cell death and injury mediated by secondary damage, which potentially reversible components of the injury response provide important targets for neuroprotective interventions.
Journal Article
Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation.
TL;DR: It is concluded that apoptosis of endothelial cells initiates acuteBBB disruption in the CNS after irradiation and that acute BBB disruption after irradiate is mediated by the ASMase pathway.
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Reirradiation human spinal cord tolerance for stereotactic body radiotherapy.
Arjun Sahgal,Lijun Ma,Vivian Weinberg,Iris C. Gibbs,Samuel T. Chao,Ung Kyu Chang,Maria Werner-Wasik,Liliyanna Angelov,Eric L. Chang,Moon Jun Sohn,Scott G. Soltys,Daniel Letourneau,Sam Ryu,Peter C. Gerszten,Jack F. Fowler,C. Shun Wong,David A. Larson +16 more
TL;DR: SBRT given at least 5 months after conventional palliative radiotherapy with a reirradiation thecal sac P(max) nBED of 20-25 Gy(2/2) appears to be safe provided the total P( Max) n BED does not exceed approximately 70 Gy( 2/2), and the SBRT thecalsac P( max) nNBED comprises no more than approximately 50% of the total nB ED.
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Probabilities of Radiation Myelopathy Specific to Stereotactic Body Radiation Therapy to Guide Safe Practice
Arjun Sahgal,Arjun Sahgal,Vivian Weinberg,Lijun Ma,Eric L. Chang,Samuel T. Chao,Alexander Muacevic,Alessandra Gorgulho,Scott G. Soltys,Peter C. Gerszten,Sam Ryu,Lilyana Angelov,Iris C. Gibbs,C. Shun Wong,David A. Larson +14 more
TL;DR: The first logistic regression model yielding estimates for the probability of human RM specific to SBRT is reported, and concordance of both tests at each specified volume was greatest for the Pmax volume.
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Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor.
TL;DR: VEGF expression appears to play an important role in CNS radiation injury, and genes induced in response to hypoxia as targets for therapy to reduce or prevent CNS radiation damage are focused on.