The flavonoid quercetin (3,3′,4′,5,7-pentahydroxyflavone) is widely distributed in plants, foods, and beverages. This polyphenol compound exhibits varied biological actions such as antioxidant, radical-scavenging, anti-inflammatory, antibacterial, antiviral, gastroprotective, immune-modulator, and finds also application in the treatment of obesity, cardiovascular diseases and diabetes. Besides, quercetin can prevent neurological disorders and exerts protection against mitochondrial damages. Various in vitro studies have assessed the anticancer effects of quercetin, although there are no conclusive data regarding its mode of action. However, low bioavailability, poor aqueous solubility as well as rapid body clearance, fast metabolism and enzymatic degradation hamper the use of quercetin as therapeutic agent, so intense research efforts have been focused on the modification of the quercetin scaffold to obtain analogs with potentially improved properties for clinical applications. This review gives an overview of the developments in the synthesis and anticancer-related activities of quercetin derivatives reported from 2012 to 2016.

https://www.mdpi.com/1420-3049/22/8/1270/pdf

Research Progress in the Modification of Quercetin Leading to Anticancer Agents.

Organo-tin antitumor compounds: Their present status in drug development and future perspectives

Effect of structure and composition of nickel(II) complexes with salicylidene Schiff base ligands on their DNA/protein interaction and cytotoxicity.

Organotin(IV) complexes derived from Schiff base N'-[(1E)-(2-hydroxy-3-methoxyphenyl)methylidene]pyridine-4-carbohydrazone: synthesis, in vitro cytotoxicities and DNA/BSA interaction.

Anti-proliferative and antitumor activity of organotin(IV) compounds. An overview of the last decade and future perspectives.

Di- and tri-organotin(IV) complexes with 2-hydroxy-1-naphthaldehyde 5-chloro-2-hydroxybenzoylhydrazone: Synthesis, characterization and in vitro antitumor activities

Syntheses, structural characterization, in vitro cytotoxicities and DNA-binding properties of triphenylantimony di(N-oxy phthalimide) and di(N-oxy succinimide) complexes

Synthesis, structural characterization and in vitro cytotoxicity of diorganotin (IV) diimido complexes

Reaction of triphenylantimony dichloride with benzohydroxamic acid or N-phenylbenzohydroxamic acid in 1 : 1 stoichiometry yielded two new triphenylantimony derivatives formulated as [Ph3SbL1L2] (L1 = benzohydroxamato, L2 = methoxide, 1; L1 = N-phenylbenzohydroxamato, L2 = Cl, 2), which have been characterized by FT-IR, NMR spectroscopy, elemental analysis, and melting point. Single-crystal X-ray diffraction analyses for 1 and 2 reveal that the antimony is six-coordinate adopting distorted octahedral geometry with one phenyl and methoxide or chloride in axial positions. In the supramolecular structure, a double-chain is shown for 2 constructed by C–H ··· X (X = O, C or π) weak interactions, while 1 exhibits a 1-D-chain structure connected by O–H ··· O and N–H ··· N hydrogen bonds. In vitro antitumor study reveals that 1 and 2 display activities against two human tumor cell lines – A549 and HCT-8. To explore the antitumor activity mechanism, DNA binding properties of 1 and 2 with calf thymus DNA (ct-DNA) ha...

Synthesis, crystal structure, and bioactivity of two triphenylantimony derivatives with benzohydroxamic acid and N-phenylbenzohydroxamic acid

In the title compound, [Sn(CH3)2(C14H9ClN2O3)], the SnIV ion is coordinated by one N and two O atoms from the tridentate 5-chloro-2-hy­droxy-N′-(2-oxidobenzyl­idene)benzohydrazidate (L) ligand and two methyl groups in a distorted trigonal–bipyramidal geometry. In the ligand, the hy­droxy group is involved in an intra­molecular O—H⋯N hydrogen bond and the two aromatic rings form a dihedral angle of 5.5 (1)°. In the crystal, weak inter­molecular C—H⋯O hydrogen bonds and π–π inter­actions between the aromatic rings [centroid–centroid distance = 3.816 (3) A] link the mol­ecules into centrosymmetric dimers.

https://journals.iucr.org/e/issues/2011/08/00/cv5115/cv5115.pdf

Caihong Yue

Papers

Di- and tri-organotin(IV) complexes with 2-hydroxy-1-naphthaldehyde 5-chloro-2-hydroxybenzoylhydrazone: Synthesis, characterization and in vitro antitumor activities

Syntheses, structural characterization, in vitro cytotoxicities and DNA-binding properties of triphenylantimony di(N-oxy phthalimide) and di(N-oxy succinimide) complexes

Synthesis, structural characterization and in vitro cytotoxicity of diorganotin (IV) diimido complexes

Synthesis, crystal structure, and bioactivity of two triphenylantimony derivatives with benzohydroxamic acid and N-phenylbenzohydroxamic acid

[5-Chloro-2-hydroxy-N′-(2-oxidobenzylidene)benzohydrazidato]dimethyltin(IV)

Caihong Yue

Papers

Di- and tri-organotin(IV) complexes with 2-hydroxy-1-naphthaldehyde 5-chloro-2-hydroxybenzoylhydrazone: Synthesis, characterization and in vitro antitumor activities

Syntheses, structural characterization, in vitro cytotoxicities and DNA-binding properties of triphenylantimony di(N-oxy phthalimide) and di(N-oxy succinimide) complexes

Synthesis, structural characterization and in vitro cytotoxicity of diorganotin (IV) diimido complexes

Synthesis, crystal structure, and bioactivity of two triphenylantimony derivatives with benzohydroxamic acid and N-phenylbenzohydroxamic acid

[5-Chloro-2-hy­droxy-N′-(2-oxidobenzyl­idene)benzohydrazidato]dimethyl­tin(IV)

[5-Chloro-2-hydroxy-N′-(2-oxidobenzylidene)benzohydrazidato]dimethyltin(IV)