C
Caixia Gao
Researcher at Chinese Academy of Sciences
Publications - 177
Citations - 18934
Caixia Gao is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Genome editing & CRISPR. The author has an hindex of 46, co-authored 143 publications receiving 12339 citations.
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Journal ArticleDOI
Targeted genome modification of crop plants using a CRISPR-Cas system.
Qiwei Shan,Yanpeng Wang,Jun Li,Yi Zhang,Kunling Chen,Zhen Liang,Kang Zhang,Jinxing Liu,Jianzhong Jeff Xi,Jin-Long Qiu,Caixia Gao +10 more
TL;DR: This work, together with the mice work, demonstrates that it should be feasible to produce genetargeted models in rodents and probably other mammalian species using the CRISPRCas systems.
Journal ArticleDOI
Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew
TL;DR: It is shown that TALEN-induced mutation of all three TaMLO homoeologs in the same plant confers heritable broad-spectrum resistance to powdery mildew, and provides a methodological framework to improve polyploid crops.
Journal ArticleDOI
CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture
TL;DR: The applications of genome editing for trait improvement, development of techniques for fine-tuning gene regulation, strategies for breeding virus resistance, and the use of high-throughput mutant libraries are summarized.
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Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes
Zhen Liang,Kunling Chen,Tingdong Li,Yi Zhang,Yanpeng Wang,Qian Zhao,Jinxing Liu,Huawei Zhang,Cuimin Liu,Yidong Ran,Caixia Gao +10 more
TL;DR: Deep sequencing reveals that the chance of off-target mutations in wheat cells is much lower in RNP mediated genome editing than in editing with CRISPR/Cas9 DNA, and the mutants obtained are completely transgene free.
Journal ArticleDOI
Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA.
TL;DR: This transient expression-based genome-editing system is highly efficient and specific for producing transgene-free and homozygous wheat mutants in the T0 generation, and may be applicable to other plant species.