C
Cameron Semper
Researcher at University of Calgary
Publications - 13
Citations - 289
Cameron Semper is an academic researcher from University of Calgary. The author has contributed to research in topics: Biology & Peptide sequence. The author has an hindex of 5, co-authored 8 publications receiving 200 citations.
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Evolution of group II introns
Steven Zimmerly,Cameron Semper +1 more
TL;DR: The different forms of group II introns known to exist in nature are described and then how these forms may have evolved to give rise to spliceosomal introns and other genetic elements are addressed.
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Structural characterization of Nonstructural protein 1 from SARS-CoV-2.
TL;DR: The crystal structure of the globular domain of SARS-CoV-2 Nsp1 is reported, encompassing residues 13 to 127, at a resolution of 1.65 Å, and reveals how variations in amino acid sequence manifest as distinct structural features.
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A reverse transcriptase-related protein mediates phage resistance and polymerizes untemplated DNA in vitro
TL;DR: Biochemically characterized a RT-related protein, AbiK, which is required for abortive phage infection in the Gram-positive bacterium Lactococcus lactis, and Mutagenesis experiments indicate that the polymerase activity resides in the RT motifs and is essential for phage resistance in vivo.
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Group II introns: versatile ribozymes and retroelements.
TL;DR: The properties of group II introns have been exploited to develop group II intron‐based biotechnological tools and of particular interest are the eukaryotic derivatives—thespliceosome, spliceosomal introns, and non‐LTR retroelements—which together make up approximately half of the human genome.
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Recombinant production of growth factors for application in cell culture
Meenakshi Venkatesan,Cameron Semper,Rosa DiLeo,Nathalie Mesa,Peter J. Stogios,Alexei Savchenko +5 more
TL;DR: In this paper , a set of expression constructs and a simplified protocol for recombinant production of functionally active protein growth factors (GFs) including FGF2, IGF1, PDGF-BB, and TGF-β1 in Escherichia coli were presented.