Showing papers in "iScience in 2022"

TL;DR: In this paper , the role of the P681H mutation in B.1.7 S1/S2 cleavage site was investigated and no significant difference in furin cleavage was observed.

TL;DR: In this article , the authors monitored the SARS-CoV-2 specific immune response in COVID-19 patients followed up to 15 months after symptoms onset and found that after a peak at day 15-28 postinfection, the IgG antibody response and plasma neutralizing titers gradually decreased over time but stabilized after 6 months.

TL;DR: In this article , the protein-protein interactions of SARS-CoV-2 proteins, including an evolutionarily conserved specific interaction of N with the stress granule resident proteins G3BP1 and G3BPs, were investigated.

TL;DR: In this paper , a review of machine learning tools categorized as either general-purpose or task-specific, covering both supervised and unsupervised learning for integrative analysis of multi-omics data is presented.

TL;DR: In this article , the effect of SARS-CoV-2 infection on placental function is not well understood, but placentas from two mothers with symptomatic COVID-19 whose pregnancies resulted in adverse outcomes for the fetuses contained high levels of viral Alpha variant RNA.

TL;DR: In this paper , the authors presented comprehensive discussions and insightful evaluations of both conventional electric vehicle (EV) batteries and the state-of-the-art battery technologies (such as all-solid-state, silicon-based, lithium-sulphur, metal-air batteries, etc.).

TL;DR: In this article , the authors present the current status of commercial direct air capture (DAC) technologies and elucidate the five pillars of technology including capture technologies, their energy demand, final costs, environmental impacts, and political support.

TL;DR: A review of theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport, can be found in this article .

TL;DR: In this paper , a 3D structure shaped by curled 2D porous surface is proposed to overcome the easy-agglomeration issue of 2D materials and meanwhile maintains their conductivity.

TL;DR: SARM1 has the highest transglycosidation (base exchange) activity at neutral pH, and with some bases this dominates NAD(P) hydrolysis and cyclization as discussed by the authors .

TL;DR: In this paper , the authors present the recent progress in green CDs, including their synthesis methods and sensing applications for the detection of heavy metal ions such as Iron (III), Mercury (II), Copper (II, Chromium (VI), Lead (II) and Arsenic (III) which are prominent environmental pollutants.

TL;DR: In this article , the authors reviewed, compared, and analyzed previous studies on vibration energy harvesting and related technologies, including electromagnetic harvesters, piezoelectric harveters, triboelectrics, and hydraulic harvester, and summarized the structure, output performance, merits and disadvantages of different energy harvesting strategies.

TL;DR: In this article , the authors characterized the proteomes of macrophages with altered Nrf2 status revealing significant differences among the genotypes in metabolism and redox homeostasis, which were validated with respirometry and metabolomics.

TL;DR: In this article , the authors provide an overview of the recent advances in the fabrication and application of high-performance flexible pressure sensors via engineering microstructures, including micropatterned, porous, fiber-network, and multiple micro-structures.

TL;DR: In this paper , a strategy that promotes acceptor and donor to crystallize separately was proposed, and an interpenetrating network with high crystallinity and proper domain size was obtained, which boosted the power conversion efficiency to 7.59%.

TL;DR: In this paper , a fully printed, highly conductive, flexible, and machine-washable e-textiles platform that stores energy and monitor physiological conditions including bio-signals is presented.

TL;DR: In this article , the authors investigated whether Akkermansia muciniphila-conditioned medium (CM) could initiate α-synuclein (αSyn) misfolding in enteroendocrine cells (EEC).

TL;DR: In this article , Bacteroides ovatus was found to produce acetic acid, propionic acid, isobutyric acid, and isovaleric acid in the intestines of mice.

TL;DR: In this paper , the authors proposed novel and scalable strategies to fabricate 2D vertical and lateral heterojunctions, consisting of semiconductors, metals, and/or semimetals.

TL;DR: In this article , the authors describe advances in preclinical models for NAFLD-NASH, the recent introduction of novel technologies in this space, and their importance for drug discovery endeavors in the future.

TL;DR: In this article , a review of Bifidobacterium spp. structures and functions of oligosaccharides is presented, along with the genes needed for their digestion and strategies adopted by bacteria for their utilization.

TL;DR: In this paper , the authors provide a comprehensive review of the current literature on how these aspects affect the overall performance of CO2 electrolysis, and the key indicators for current density, selectivity, cell voltage, and lifetime of a CO 2 electrolyzer mentioned in the techno-economic consideration of this review are met.

TL;DR: Slide-seqV2 as mentioned in this paper was applied to mouse and human kidneys, in healthy and distinct disease paradigms, and it revealed a cell neighborhood centered around a population of LYVE1+ macrophages.

TL;DR: In this paper , the crystal structure, thermal conductivity, thermal expansion coefficient, morphology, composition, and thermal durability of LaSmZrO coatings were investigated under high temperature.

TL;DR: Chitosan (CS) and graphene oxide (GO) nanocomposites have received wide attention in biomedical fields due to the synergistic effect between CS which has excellent biological characteristics and GO which owns great physicochemical, mechanical and optical properties as discussed by the authors .

TL;DR: In this paper , a review of recent progress in the synthesis of 2D metal oxides is summarized and categorized, followed by a critical discussion of various synthesis methods regarding the growth mechanisms, advantages, and limitations.

TL;DR: In this article , the authors reviewed the successful applications of UEMLs in OLEDs and underlying working mechanism of corresponding devices, and also emphasized the representative achievements about OLEDs with UEMls.

TL;DR: In this article , the authors describe the collateral single-stranded DNA cleavage with Class 1 type I CRISPR-Cas3 and highlight its potential for development as a Cas3-mediated rapid (within 40 min), low-cost, instrument-free detection method for SARS-CoV-2.

TL;DR: In this paper , the authors quantify changes in electricity consumption in 58 different countries/regions around the world from January-October 2020 and examine how those changes relate to government restrictions, health outcomes, GDP, mobility metrics, and electricity sector characteristics in different countries.