C
Camilla Costagli
Researcher at University of Florence
Publications - 10
Citations - 363
Camilla Costagli is an academic researcher from University of Florence. The author has contributed to research in topics: GABAA receptor & Receptor. The author has an hindex of 8, co-authored 10 publications receiving 322 citations.
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Journal ArticleDOI
2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands
Silvia Selleri,Fabrizio Bruni,Camilla Costagli,Annarella Costanzo,Gabriella Guerrini,Giovanna Ciciani,Barbara Costa,Claudia Martini +7 more
TL;DR: A new class of N,N-diethyl-(2-arylpyrazolo[1,5-a]pyrimidin-3-yl)acetamides (3f-y), as azaisosters of Alpidem, was prepared following a novel synthetic method and their affinities for both the peripheral (PBR) and the central (CBR) benzodiazepine receptors were evaluated.
Journal ArticleDOI
A novel selective GABA(A) alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents.
Silvia Selleri,Fabrizio Bruni,Camilla Costagli,Annarella Costanzo,Gabriella Guerrini,Giovanna Ciciani,Paola Gratteri,François Besnard,Barbara Costa,Marina Montali,Claudia Martini,Jonna Fohlin,Gaetano De Siena,Petra Malmberg Aiello +13 more
TL;DR: A novel pyrazolo[1,5-a]pyrimidine derivative, the azaisostere of zolpidem, was synthesized and evaluated in vitro on bovine brain homogenate and on recombinant benzodiazepine receptors (alphaxbeta2/3gamma2, x = 1-3, 5) expressed in HEK293 cells.
Journal ArticleDOI
Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: synthesis, biological evaluation and 3D-QSAR investigation.
Silvia Selleri,Paola Gratteri,Camilla Costagli,Claudia Bonaccini,Annarella Costanzo,Fabrizio Melani,Gabriella Guerrini,Giovanna Ciciani,Barbara Costa,F Spinetti,Claudia Martini,Fabrizio Bruni +11 more
TL;DR: The synthesis and binding studies of new 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as selective Peripheral Benzodiazepine Receptor (PBR) ligands are reported and a subset of the novel compounds showing high affinity for PBR was tested for their ability to modulate the steroid biosynthesis in C6 glioma cells.
Journal ArticleDOI
Benzodiazepine receptor ligands. 8: synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy.
Gabriella Guerrini,Annarella Costanzo,Giovanna Ciciani,Fabrizio Bruni,Silvia Selleri,Camilla Costagli,François Besnard,Barbara Costa,Claudia Martini,Gaetano De Siena,Petra Malmberg-Aiello +10 more
TL;DR: The synthesis and the binding study of new 3-arylesters and 3-heteroarylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide 8-substituted are reported, and the nature of these substituents seems to influence the binding affinity.
Journal ArticleDOI
Synthesis and benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. 3. New 6-(3-thienyl) series as alpha 1 selective ligands.
Silvia Selleri,Fabrizio Bruni,Camilla Costagli,Annarella Costanzo,Gabriella Guerrini,Giovanna Ciciani,Paola Gratteri,Claudia Bonaccini,Petra Malmberg Aiello,François Besnard,Stéphane Renard,Barbara Costa,Claudia Martini +12 more
TL;DR: New 3-aryl-6-(3-thienyl)pyrazolo[1,5-a]pyrimidin-7-ones (2a-j) are synthesized and evaluated in vitro on Bz/GABA(A) receptors and on recombinant benzodiazepine receptors (alpha x beta 2/3 gamma 2; x = 1-3, 5) expressed in HEK293 cells.