F
Fabrizio Bruni
Researcher at University of Florence
Publications - 63
Citations - 866
Fabrizio Bruni is an academic researcher from University of Florence. The author has contributed to research in topics: Pyrimidine & Receptor. The author has an hindex of 18, co-authored 63 publications receiving 798 citations.
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Journal ArticleDOI
2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands
Silvia Selleri,Fabrizio Bruni,Camilla Costagli,Annarella Costanzo,Gabriella Guerrini,Giovanna Ciciani,Barbara Costa,Claudia Martini +7 more
TL;DR: A new class of N,N-diethyl-(2-arylpyrazolo[1,5-a]pyrimidin-3-yl)acetamides (3f-y), as azaisosters of Alpidem, was prepared following a novel synthetic method and their affinities for both the peripheral (PBR) and the central (CBR) benzodiazepine receptors were evaluated.
Journal ArticleDOI
A novel selective GABA(A) alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents.
Silvia Selleri,Fabrizio Bruni,Camilla Costagli,Annarella Costanzo,Gabriella Guerrini,Giovanna Ciciani,Paola Gratteri,François Besnard,Barbara Costa,Marina Montali,Claudia Martini,Jonna Fohlin,Gaetano De Siena,Petra Malmberg Aiello +13 more
TL;DR: A novel pyrazolo[1,5-a]pyrimidine derivative, the azaisostere of zolpidem, was synthesized and evaluated in vitro on bovine brain homogenate and on recombinant benzodiazepine receptors (alphaxbeta2/3gamma2, x = 1-3, 5) expressed in HEK293 cells.
Journal ArticleDOI
Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: synthesis, biological evaluation and 3D-QSAR investigation.
Silvia Selleri,Paola Gratteri,Camilla Costagli,Claudia Bonaccini,Annarella Costanzo,Fabrizio Melani,Gabriella Guerrini,Giovanna Ciciani,Barbara Costa,F Spinetti,Claudia Martini,Fabrizio Bruni +11 more
TL;DR: The synthesis and binding studies of new 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as selective Peripheral Benzodiazepine Receptor (PBR) ligands are reported and a subset of the novel compounds showing high affinity for PBR was tested for their ability to modulate the steroid biosynthesis in C6 glioma cells.
Journal ArticleDOI
Benzodiazepine Receptor Ligands. 4. Synthesis and Pharmacological Evaluation of 3-Heteroaryl-8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-Oxides
Annarella Costanzo,Gabriella Guerrini,Giovanna Ciciani,Fabrizio Bruni,Silvia Selleri,Barbara Costa,Claudia Martini,Antonio Lucacchini,Petra Malmberg Aiello,Alessandra Ipponi +9 more
TL;DR: In in vivo tests the 3-(thien-3-yl)-8-chloropyrazolo[5,1-c][1,2,4] benzotriazine 5-oxide (13d) showed selective anticonvulsant activity.
Journal ArticleDOI
2-Phenylpyrazolo[1,5-a]pyrimidin-7-ones. A new class of nonsteroidal antiinflammatory drugs devoid of ulcerogenic activity.
G. Auzzi,Fabrizio Bruni,Lucia Cecchi,Annarella Costanzo,Lorenzo Vettori,Renato Pirisino,Marina Corrias,G. Ignesti,Grazia Banchelli,Laura Raimondi +9 more
TL;DR: 4-Ethyl-4,7-dihydro-2-phenylpyrazolo [1,5-a]pyrimidin-7-one (3) showed the highest activity and a better therapeutic index than phenylbutazone and indomethacin, used as reference drugs.