C
Camilla K. Smith Pease
Researcher at Imperial College London
Publications - 4
Citations - 231
Camilla K. Smith Pease is an academic researcher from Imperial College London. The author has contributed to research in topics: Aldehyde dehydrogenase & Alcohol dehydrogenase. The author has an hindex of 4, co-authored 4 publications receiving 217 citations.
Papers
More filters
Journal ArticleDOI
Protein Binding and Metabolism Influence the Relative Skin Sensitization Potential of Cinnamic Compounds
Eiram N. Elahi,Zoe Wright,David C. Hinselwood,Sharon A.M. Hotchkiss,D. A. Basketter,Camilla K. Smith Pease +5 more
TL;DR: The work presented here suggests that there is a common hapten involved in cinnamaldehyde and cinnamic alcohol sensitization and that metabolic activation (to cinn amaldehyde) is involved in the latter.
Journal ArticleDOI
Cinnamic compound metabolism in human skin and the role metabolism may play in determining relative sensitisation potency
TL;DR: This study has demonstrated that cutaneous ADH and ALDH activities, located within defined subcellular compartments, play important roles in the activation and detoxification of CAlc and CAld in skin.
Journal ArticleDOI
Species variations in cutaneous alcohol dehydrogenases and aldehyde dehydrogenases may impact on toxicological assessments of alcohols and aldehydes
TL;DR: The class-specific expression of ADH and ALDH enzymes, in the skin and liver and their variation between species, may have toxicological significance, with respect to the metabolism of endogenous and xenobiotic alcohols and aldehydes.
Journal ArticleDOI
From xenobiotic chemistry and metabolism to better prediction and risk assessment of skin allergy
TL;DR: This review explores general chemical and metabolic aspects in relation to the potential formation of protein-hapten conjugates and a prototypical group of xenobiotics used to explore sensitisation mechanisms in some detail are selected cinnamic derivatives.