Jan-Olov Höög

TL;DR: A nomenclature that uses the widely accepted vertebrate ADH class system as its basis and will accommodate newly discovered members of the vertebrates ADH family, and will facilitate functional and evolutionary studies.

TL;DR: Repeated duplications can be traced for the alcohol dehydrogenases, with independent enzymogenesis of ethanol activity, showing a general importance of this enzyme activity.

TL;DR: Significantly higher levels of class V transcripts were present in fetal liver when compared with levels in adult liver, which suggests that human class V is a predominantly fetal alcohol dehydrogenase.

TL;DR: Six different classes of mammalian alcohol dehydrogenase have been characterized, most of which are common to humans, mammals and many vertebrates, which therefore share class distinctions in general.

TL;DR: Conformational models of the three characterized classes of mammalian liver alcohol dehydrogenase were constructed using computer graphics based on the known three-dimensional structure of the E subunit of the horse enzyme and the primary structures of the four human enzyme classes to correlate the substrate-binding pockets with those of the class II and III subunits for three enzymes that differ in substrate specificity, inhibition pattern and many other properties.