C
Camille Locht
Researcher at Pasteur Institute
Publications - 407
Citations - 20935
Camille Locht is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Bordetella pertussis & Mycobacterium tuberculosis. The author has an hindex of 75, co-authored 394 publications receiving 19738 citations. Previous affiliations of Camille Locht include University of Łódź & Centre national de la recherche scientifique.
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Journal ArticleDOI
Proposal for Standardization of Optimized Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing of Mycobacterium tuberculosis
Philip Supply,Philip Supply,Caroline Allix,Sarah Lesjean,Sarah Lesjean,Mara Cardoso-Oelemann,Mara Cardoso-Oelemann,Sabine Rüsch-Gerdes,Eve Willery,Eve Willery,Evgueni Savine,Evgueni Savine,Petra E. W. de Haas,Henk van Deutekom,Solvig Roring,Pablo Bifani,Natalia Kurepina,Barry N. Kreiswirth,Christophe Sola,Nalin Rastogi,Vincent Vatin,Vincent Vatin,Maria Cristina Gutierrez,Maryse Fauville,Stefan Niemann,Robin A. Skuce,Kristin Kremer,Camille Locht,Camille Locht,Dick van Soolingen +29 more
TL;DR: A discriminatory subset of 15 loci with the highest evolutionary rates was defined that concentrated 96% of the total resolution obtained with the full 24-locus set, and its predictive value for evaluating M. tuberculosis transmission was found to be equal to that of IS6110 restriction fragment length polymorphism typing.
Journal ArticleDOI
Automated High-Throughput Genotyping for Study of Global Epidemiology of Mycobacterium tuberculosis Based on Mycobacterial Interspersed Repetitive Units
TL;DR: Kremer et al. as mentioned in this paper used variable-number tandem repeat (VNTR) of genetic elements named mycobacterial interspersed repetitive units (MIRUs) in 12 mammalian minisatellite-like loci of M. tuberculosis.
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Variable human minisatellite-like regions in the Mycobacterium tuberculosis genome.
TL;DR: Of the 12 variable loci, only one was found to vary among genealogically distant BCG substrains, suggesting that these interspersed bacterial minisatellite‐like structures evolve slowly in mycobacterial populations.
Journal ArticleDOI
Origin, Spread and Demography of the Mycobacterium tuberculosis Complex
Thierry Wirth,Falk Hildebrand,Caroline Allix-Béguec,Florian Wölbeling,Tanja Kubica,Kristin Kremer,Dick van Soolingen,Sabine Rüsch-Gerdes,Camille Locht,Camille Locht,Sylvain Brisse,Axel Meyer,Philip Supply,Philip Supply,Stefan Niemann +14 more
TL;DR: It is shown that the Mycobacterium tuberculosis complex consists of two independent clades, one composed exclusively of M. tuberculosis lineages from humans and the other composed of both animal and human isolates, supporting the hypothesis of an original human host.
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High-resolution minisatellite-based typing as a portable approach to global analysis of Mycobacterium tuberculosis molecular epidemiology
Edith Mazars,Sarah Lesjean,Anne-Laure Bañuls,Michèle Gilbert,Véronique Vincent,Brigitte Gicquel,Michel Tibayrenc,Camille Locht,Philip Supply +8 more
TL;DR: A high-resolution typing method based on variable number tandem repeats (VNTRs) of genetic elements named mycobacterial interspersed repetitive units (MIRUs) in 12 human minisatellite-like regions of the M. tuberculosis genome that opens the way to the construction of digital global databases for molecular epidemiology studies of M.culosis.