C
Cancer Genome
Researcher at Institute of Cancer Research
Publications - 2
Citations - 2610
Cancer Genome is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Kinase activity & Phosphorylation. The author has an hindex of 2, co-authored 2 publications receiving 2438 citations. Previous affiliations of Cancer Genome include Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Paul T C Wan,Mathew J. Garnett,S. Mark Roe,Sharlene Lee,Dan Niculescu-Duvaz,Valerie M. Good,Cancer Genome,C. Michael Jones,Christopher J. Marshall,Caroline J. Springer,David Barford,Richard Marais +11 more
TL;DR: The high activity mutants signal to ERK by directly phosphorylating MEK, whereas the impaired activity mutants stimulate MEK by activating endogenous C-RAF, possibly via an allosteric or transphosphorylation mechanism.
Journal ArticleDOI
Identification of inhibitors of the kinase activity of oncogenic V600E BRAF in an enzyme cascade high-throughput screen.
Yvette Newbatt,Samantha Burns,Robert Hayward,Steven R. Whittaker,Ruth Kirk,Christopher J. Marshall,Caroline J. Springer,Edward McDonald,Cancer Genome,Richard Marais,Paul Workman,Wynne Aherne +11 more
TL;DR: A high-throughput screen to find inhibitors of V600EBRAF using an enzyme cascade assay in which oncogenic BRAF activates MEK1, which in turn activates ERK2, which then phosphorylates the transcription factor ELK1.