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Candace C. Keefe
Researcher at Harvard University
Publications - 5
Citations - 191
Candace C. Keefe is an academic researcher from Harvard University. The author has contributed to research in topics: Polycystic ovary & Blood sampling. The author has an hindex of 5, co-authored 5 publications receiving 162 citations.
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Journal ArticleDOI
Simultaneous measurement of thirteen steroid hormones in women with polycystic ovary syndrome and control women using liquid chromatography-tandem mass spectrometry.
Candace C. Keefe,Mildred M. Goldman,Ke Zhang,Nigel J. Clarke,Richard E. Reitz,Corrine K. Welt +5 more
TL;DR: Findings that the ovary is an important source for the androgen excess in women with PCOS are supported, and testosterone measurements were better matched in the two assays.
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Metformin improves glucose effectiveness, not insulin sensitivity: predicting treatment response in women with polycystic ovary syndrome in an open-label, interventional study.
TL;DR: Using an IV glucose tolerance test, metformin does not improve insulin sensitivity in women with PCOS but does improve glucose effectiveness, and the improvement in glucose effectiveness may be partially mediated by decreased glucose levels.
Journal ArticleDOI
Identification of subjects with polycystic ovary syndrome using electronic health records
Victor Castro,Yuanyuan Shen,Sheng-Chun Yu,Sean Finan,Cindy T. Pau,Vivian S. Gainer,Candace C. Keefe,Guergana Savova,Shawn N. Murphy,Tianxi Cai,Corrine K. Welt +10 more
TL;DR: Extraction of text parameters along with codified data improves the confidence in PCOS patient cohorts identified using the electronic medical record, but the positive predictive value was not significantly different when using ICD-9 codes or the specific algorithm.
Journal ArticleDOI
Cigarette smoking, nicotine levels and increased risk for metabolic syndrome in women with polycystic ovary syndrome.
TL;DR: Smoking may worsen the already high risk for metabolic syndrome in women with PCOS, which may be exacerbated by smoking.
Journal ArticleDOI
The role of variants regulating metformin transport and action in women with polycystic ovary syndrome.
Cindy T. Pau,Kai I. Cheang,Bhavi P. Modi,Thushiga Kasippillai,Thushiga Kasippillai,Candace C. Keefe,Maria Shulleeta,William S. Evans,Lubna Pal,Jerome F. Strauss,John E. Nestler,Corrine K. Welt,Corrine K. Welt +12 more
TL;DR: Variants in organic ion transporters do not explain the variable metformin response in polycystic ovary syndrome.