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Nigel J. Clarke
Researcher at Quest Diagnostics
Publications - 115
Citations - 3262
Nigel J. Clarke is an academic researcher from Quest Diagnostics. The author has contributed to research in topics: Mass spectrometry & Metabolite. The author has an hindex of 30, co-authored 112 publications receiving 2784 citations. Previous affiliations of Nigel J. Clarke include Samsung & University of Waterloo.
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Journal ArticleDOI
Resilient 3D hierarchical architected metamaterials
Lucas R. Meza,Alex J. Zelhofer,Nigel J. Clarke,Arturo J. Mateos,Dennis M. Kochmann,Julia R. Greer +5 more
TL;DR: It is shown, through a combination of experiments and computations, that introducing hierarchy into the architecture of 3D structural metamaterials enables the attainment of a unique combination of properties: ultralightweight, recoverability, and a near-linear scaling of stiffness and strength with density.
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Advantages and challenges of mass spectrometry assays for steroid hormones
TL;DR: The present review discusses the advantages of MS assays over conventional RIAs and direct immunoassays in steroid hormone measurements, and points out some of the important challenges facing the rapid increase in usage of MS Assays.
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Recommendations for the Generation, Quantification, Storage, and Handling of Peptides Used for Mass Spectrometry–Based Assays
Andrew N. Hoofnagle,Jeffrey R. Whiteaker,Steven A. Carr,Eric Kuhn,Tao Liu,Sam A. Massoni,Stefani N. Thomas,Raymond R. Townsend,Lisa J. Zimmerman,Emily S. Boja,Jing Chen,Daniel L. Crimmins,Sherri R. Davies,Yuqian Gao,Tara Hiltke,Karen A. Ketchum,Christopher R. Kinsinger,Mehdi Mesri,Matthew R. Meyer,Wei-Jun Qian,Regine M. Schoenherr,Mitchell G. Scott,Tujin Shi,Gordon Whiteley,John A. Wrobel,Chaochao Wu,Brad Ackermann,Ruedi Aebersold,David R. Barnidge,David M. Bunk,Nigel J. Clarke,Jordan B. Fishman,Russ P. Grant,Ulrike Kusebauch,Mark M. Kushnir,Mark S. Lowenthal,Robert L. Moritz,Hendrik Neubert,Scott D. Patterson,Alan L. Rockwood,John C. Rogers,Ravinder J. Singh,Jennifer E. Van Eyk,Steven H. Wong,Shucha Zhang,Daniel W. Chan,Xian Chen,Matthew J. Ellis,Daniel C. Liebler,Karin D. Rodland,Henry Rodriguez,Richard D. Smith,Zhen Zhang,Hui Zhang,Amanda G. Paulovich +54 more
TL;DR: The Clinical Proteomic Tumor Analysis Consortium of the National Cancer Institute has collaborated with clinical laboratorians, peptide manufacturers, metrologists, representatives of the pharmaceutical industry, and other professionals to develop a consensus set of recommendations for peptide procurement, characterization, storage, and handling.
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Interlaboratory comparison study of serum total testoserone measurements performed by mass spectrometry methods
Hubert W. Vesper,Shalender Bhasin,Christina Wang,Susan S. Tai,Larry A. Dodge,Ravinder J. Singh,Judie Nelson,Susan Ohorodnik,Nigel J. Clarke,Wael A. Salameh,C. Richard Parker,Raj Razdan,Elizabeth A. Monsell,Gary L. Myers +13 more
TL;DR: The variability of TT measurement results among MS assays is substantially smaller than that reported for immunoassays, and standardizing assays can further reduce the variability of measurement results.
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Validation of a total testosterone assay using high-turbulence liquid chromatography tandem mass spectrometry: total and free testosterone reference ranges.
Wael A. Salameh,Mildred M. Redor-Goldman,Nigel J. Clarke,Richard E. Reitz,Michael P. Caulfield +4 more
TL;DR: Male and female adult and pediatric reference ranges were developed for this very sensitive and accurate high-throughput LC-MS/MS method, suitable for measuring the expected low-testosterone concentrations seen in women, children, and hypogonadal males and for monitoring testosterone suppressive therapy in prostate cancer patients.